Properties of the slow inward current induced by pentylenetetrazol in Helix neurons

A. Papp, O. Fehér, L. Erdélyi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The slow inward current (SIC) induced by 50 mM pentylenetetrazol was studied on central neurons of Helix pomatia in view of its ionic dependence and sensitivity to channel blockers in the presence of 30 mM TEA. A single electrode voltage clamp was used to measure currents evoked by ramp pulses and voltage steps. Sodium withdrawal had variable effects on this current while TTX had no influence on it. Inorganic and organic calcium channel blockers, on the contrary, always produced a partial or total block of the SIC. It is concluded that the slow inward current is mediated by Ca channels impaired by PTZ. Various ions - Na, Ca, and even Tris - may participate in it variable proportions.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalEpilepsy Research
Volume6
Issue number2
DOIs
Publication statusPublished - 1990

Fingerprint

Pentylenetetrazole
Architectural Accessibility
Calcium Channel Blockers
Electrodes
Sodium
Ions
Neurons

Keywords

  • Ca channel blockers
  • Calcium ion
  • Helix neuron
  • Pentylenetetrazol
  • Slow inwaed current
  • Sodium ion

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Properties of the slow inward current induced by pentylenetetrazol in Helix neurons. / Papp, A.; Fehér, O.; Erdélyi, L.

In: Epilepsy Research, Vol. 6, No. 2, 1990, p. 119-125.

Research output: Contribution to journalArticle

Papp, A. ; Fehér, O. ; Erdélyi, L. / Properties of the slow inward current induced by pentylenetetrazol in Helix neurons. In: Epilepsy Research. 1990 ; Vol. 6, No. 2. pp. 119-125.
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