Propagation of spike and wave activity to the medial prefrontal cortex and dorsal raphe nucleus of WAG/Rij rats

Magor Lörincz, Márta Oláh, Péter Baracskay, Nora Szilágyi, Gábor Juhász

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Although there is pharmacological evidence for the involvement of the serotonergic system in the expression of spike and wave discharges (SWDs) in experimental absence epilepsy, no direct investigation of this paroxysm in the dorsal raphe nucleus (DRN), one of the main serotonergic nuclei, has been carried out. We have now recorded the EEG simultaneously with local field potentials and unit activity in DRN from WAG/Rij rats, one of the best established models of absence epilepsy during spontaneous SWDs. We have also compared this activity to that in the thalamocortical networks, where SWDs are generated, and in the medial prefrontal cortex (mPFC), as this brain area is reciprocally connected to the DRN. We have found that SWDs propagate to the DRN with a short delay, and that the firing rate of its neurons changes during this type of paroxysm. These results provide the first direct evidence for clear alterations in the firing properties of mPFC and DRN neurons during spontaneous SWDs.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalPhysiology and Behavior
Volume90
Issue number2-3
DOIs
Publication statusPublished - Feb 28 2007

Keywords

  • Absence epilepsy
  • Action potential
  • Local field potential
  • Serotonin

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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