Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria

Muhammad Jawad Nasim, Karolina Witek, Annamária Kincses, Ahmad Yaman Abdin, Ewa Żesławska, Małgorzata Anna Marć, Márió Gajdács, G. Spengler, Wojciech Nitek, Gniewomir Latacz, Elżbieta Karczewska, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik, Claus Jacob

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Selenocyanates represent an interesting class of organic selenium compounds. Due to their similarity with better known natural (iso-)thiocyanates, they promise high biological activity and may also be metabolized to other Reactive Selenium Species (RSeS), such as selenols, diselenides and seleninic acids. Thirteen arylmethyl selenocyanates (1-13) have been synthesized and evaluated for potential antimicrobial, nematicidal and cytotoxic activity. The compounds exhibit pronounced antimicrobial activity against various strains of Gram-positive and Gram-negative bacteria and yeasts, including multidrug resistant strains. The results obtained so far demonstrate that these arylmethyl selenocyanates are also non-mutagenic and have limited cytotoxicity against human cells. Here, benzyl selenocyanate (1) represents the most active anti-ESKAPE agent, with potent activity against multidrug resistant MRSA strains (HEMSA 5)-with a competitive MIC value of just 0.76 μg mL −1 (3.88 μM), whereas it exhibits low(er) cytotoxicity (IC 50 = 31 μM) and no mutagenicity against mammalian cells. Due to this selective antimicrobial activity, aromatic selenocyanates may provide an interesting lead in the development of antimicrobial agents, particularly in the context of drug resistance.

Original languageEnglish
Pages (from-to)6021-6031
Number of pages11
JournalNew Journal of Chemistry
Volume43
Issue number15
DOIs
Publication statusPublished - Jan 1 2019

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Cytotoxicity
Bacteria
Selenium compounds
Cells
Antimicrobial agents
Selenium
Bioactivity
Yeast
Thiocyanates
Lead
Selenium Compounds
Acids
Anti-Infective Agents
selenocyanic acid
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

Cite this

Nasim, M. J., Witek, K., Kincses, A., Abdin, A. Y., Żesławska, E., Marć, M. A., ... Jacob, C. (2019). Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria. New Journal of Chemistry, 43(15), 6021-6031. https://doi.org/10.1039/C9NJ00563C

Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria. / Nasim, Muhammad Jawad; Witek, Karolina; Kincses, Annamária; Abdin, Ahmad Yaman; Żesławska, Ewa; Marć, Małgorzata Anna; Gajdács, Márió; Spengler, G.; Nitek, Wojciech; Latacz, Gniewomir; Karczewska, Elżbieta; Kieć-Kononowicz, Katarzyna; Handzlik, Jadwiga; Jacob, Claus.

In: New Journal of Chemistry, Vol. 43, No. 15, 01.01.2019, p. 6021-6031.

Research output: Contribution to journalArticle

Nasim, MJ, Witek, K, Kincses, A, Abdin, AY, Żesławska, E, Marć, MA, Gajdács, M, Spengler, G, Nitek, W, Latacz, G, Karczewska, E, Kieć-Kononowicz, K, Handzlik, J & Jacob, C 2019, 'Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria', New Journal of Chemistry, vol. 43, no. 15, pp. 6021-6031. https://doi.org/10.1039/C9NJ00563C
Nasim MJ, Witek K, Kincses A, Abdin AY, Żesławska E, Marć MA et al. Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria. New Journal of Chemistry. 2019 Jan 1;43(15):6021-6031. https://doi.org/10.1039/C9NJ00563C
Nasim, Muhammad Jawad ; Witek, Karolina ; Kincses, Annamária ; Abdin, Ahmad Yaman ; Żesławska, Ewa ; Marć, Małgorzata Anna ; Gajdács, Márió ; Spengler, G. ; Nitek, Wojciech ; Latacz, Gniewomir ; Karczewska, Elżbieta ; Kieć-Kononowicz, Katarzyna ; Handzlik, Jadwiga ; Jacob, Claus. / Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria. In: New Journal of Chemistry. 2019 ; Vol. 43, No. 15. pp. 6021-6031.
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