Prolyl endopeptidase inhibitors: N-acyl derivatives of L-thioproline- pyrrolidine

Kánai Károly, Erdo Sándor, Susán Edit, Fehér Miklós, Sipos Judit, Podányi Benjámin, Szappanos Andrea, Hermecz István

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of N-acyl derivatives of thioproline-pyrrolidine was prepared conventionally and evaluated in vitro against rat brain prolyl endopeptidase (PEP). It is argued an the basis of pharmacophore plots that an optimum chain length exists as a result of increased population of pharmacophore space and decreased solubility on increasing the alkyl chain length.

Original languageEnglish
Pages (from-to)1701-1704
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number13
DOIs
Publication statusPublished - Jul 8 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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