Prolyl Endopeptidase and Dipeptidyl Peptidase IV are Distantly Related Members of the Same Family of Serine Proteases

Laszlo Polgár, Erika Szabo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Prolyl endopeptidase and dipeptidyl peptidase IV are serine proteases which cleave the peptide bonds at the carboxy group of proline residues. They do not show amino acid sequence homology with the known serine enzymes, but a possible relationship between them has not yet been examined. We have compared the amino acid sequences, and this revealed a distant evolutionary relationship between the two enzymes. Conserved Segments were found mainly in the C-terrainal region which also contained the catalytic residues. It is concluded that the C-terminal region is a Protease domain which is attached to some noncatalytic structures.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalBiological Chemistry Hoppe-Seyler
Volume373
Issue number2
DOIs
Publication statusPublished - Jan 1992

ASJC Scopus subject areas

  • Biochemistry

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