Prolonged intestinal mucosal acidosis is associated with multiple organ failure in human acute pancreatitis: Gastric tonometry revisited

Gabor C. Kovacs, Geza Telek, J. Hamar, Jozsef Furesz, Janos Regoly-Merei

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: To evaluate whether multiple determinations of intramucosal pH (pHi) in acute pancreatitis (AP) patients could provide additional information of the disease severity during early hospitalization. Methods: Twenty-one patients suffering from acute pancreatitis were monitored by gastric tonometry in the first 72 h after hospital admission. Results: In the survivor group (n = 15) the initially low pHi values returned to normal level (pHi ≥ 7.32) within 48 h (median pHi: d 1: 7.21; d 2: 7.32; d 3: 7.33). In contrast, pHi values in the non-survivor group n = 6) were persistently either below or in the low normal range (median pHi 7.12; 7.12; 7.07 respectively), but pHi differences between the two groups reached significance only after 24 h (P <0.01). Mucosal acidosis detected at any time during the monitored period was associated with the emergence of single or multiple organ dysfunction (P <0.01). Conclusion: Prolonged gastric mucosal acidosis was associated with remote organ dysfunction and failure in Acute Pancreatitis, however, correlation with the fatal outcome became significant only 24 h after admission. Due to its non-invasive nature gastric tonometry may supplement the pro-inflammatory markers to achieve a multi-faceted monitoring of the disease.

Original languageEnglish
Pages (from-to)4892-4896
Number of pages5
JournalWorld Journal of Gastroenterology
Volume12
Issue number30
Publication statusPublished - Aug 14 2006

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Multiple Organ Failure
Manometry
Acidosis
Pancreatitis
Stomach
Fatal Outcome
Survivors
Reference Values
Hospitalization

Keywords

  • Acute pancreatitis
  • Bacterial translocation
  • Human studies
  • Intramucosal pH
  • Mucosal barrier dysfunction
  • Multiple organ dysfunction
  • Septic complications

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prolonged intestinal mucosal acidosis is associated with multiple organ failure in human acute pancreatitis : Gastric tonometry revisited. / Kovacs, Gabor C.; Telek, Geza; Hamar, J.; Furesz, Jozsef; Regoly-Merei, Janos.

In: World Journal of Gastroenterology, Vol. 12, No. 30, 14.08.2006, p. 4892-4896.

Research output: Contribution to journalArticle

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