The present publication reports about the delay of the rejection by unspecific medicamentous immunosuppression. This is continuation of our earlier publication about the unaffected primary rejection of xenogenic kidney transplants in the closely related system fox - dog. The combined application of azathioprine and prednisolone leads to elongated function times of the kidney transplants and to the duplication of survival times of the recipients. Lymphocytotoxins, which are immuno-electrophoretic Ig G antibodies, appear two days later than in untreated recipients by hindrance of immunological reactivity. These obtain, however, then in consequence of the injured formation of antigen-antibody complexes, a concentration increase which widely exceeds the increase of the control groups. The influence of azathioprine and prednisolone on the humoral, respectively, cellular immunity is talked about in the discussion. Morphological differences in the transplants are not observed in comparison with untreated recipients.
|Translated title of the contribution||Prolonged function times of xenogenic kidney transplants by combined application of azathioprin and prednisolone|
|Number of pages||7|
|Journal||Zeitschrift fur experimentelle Chirurgie|
|Publication status||Published - Jan 1 1979|
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