Prolonged effect of stress at weaning on the brain serotonin metabolism and sexuality of female rats

K. Tekes, M. Hantos, M. Gyenge, Cs Karabélyos, György Csaba

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Weanling female rats were stressed (by water and food deprivation for two days) and three months later the following indexes were studied: 5-HTand 5-HIAA levels in five brain regions, blood plasma and cerebrospinal fluid (CSF), sexual activity and nocistatin level of the plasma and CSF. The 5-HIAA content of hypothalamus and brainstem was significantly decreased (in the brainstem with one third) and in the striatum significantly increased. Plasma nocistatin level was significantly increased. Meyerson index and lordosis quotient were similar to control, but the estrus frequency almost doubled in the stressed animals. Much more defense reactions were observed in the stressed females during trials of mating. The results demonstrate that, 1) the perinatal period is not only sensitive to the remote-effects of stress but later could also be stress-sensitive critical periods, and 2) the continuously differentiating (e.g. bone marrow) cells are sensitive to late imprinting by stress, as well as to the brain and the sexual system.

Original languageEnglish
Pages (from-to)799-802
Number of pages4
JournalHormone and Metabolic Research
Volume38
Issue number12
DOIs
Publication statusPublished - Dec 1 2006

Keywords

  • 5-HIAA
  • 5-HT
  • Brain serotonin
  • Nocistatin
  • Water and food deprivation
  • Weaning

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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