Prolonged effect of a single serotonin treatment in adult age on the serotonin and histamine content of white blood cells and mast cells of rats

G. Csaba, P. Kovács, E. Pállinger

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Hormonal imprinting was provoked by serotonin treatment in adult age. Three weeks after treatment with 100 μg serotonin, the serotonin and histamine content of peritoneal cells (mast cells, lymphocytes and the monocyte-macrophage-granulocyte group), white blood cells (lymphocytes, granulocytes and monocytes) and thymic lymphocytes was studied by flow cytometry. The content of both amines was significantly higher in the mast cells of males and lower in females. Blood lymphocytes contained a higher serotonin and histamine level in males, and a lower serotonin level in females. The peritoneal monocyte-macrophage-granulocyte group contained less serotonin in both males and females. Thymocytes contained higher levels of both amines in females and higher histamine level in males. The experiments demonstrate that a single treatment at adult age can provoke imprinting, which alters - in the present case - the serotonin and histamine content of immune cells durably.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalCell Biochemistry and Function
Volume21
Issue number2
DOIs
Publication statusPublished - Jun 2003

Fingerprint

Mast Cells
Histamine
Rats
Serotonin
Leukocytes
Blood
Cells
Lymphocytes
Granulocytes
Monocytes
Macrophages
Amines
Flow cytometry
Peritoneal Macrophages
Thymocytes
Flow Cytometry
Experiments

Keywords

  • Gender differences
  • Histamine
  • Hormonal imprinting
  • Mast cells
  • Serotonin
  • White blood cells

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

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abstract = "Hormonal imprinting was provoked by serotonin treatment in adult age. Three weeks after treatment with 100 μg serotonin, the serotonin and histamine content of peritoneal cells (mast cells, lymphocytes and the monocyte-macrophage-granulocyte group), white blood cells (lymphocytes, granulocytes and monocytes) and thymic lymphocytes was studied by flow cytometry. The content of both amines was significantly higher in the mast cells of males and lower in females. Blood lymphocytes contained a higher serotonin and histamine level in males, and a lower serotonin level in females. The peritoneal monocyte-macrophage-granulocyte group contained less serotonin in both males and females. Thymocytes contained higher levels of both amines in females and higher histamine level in males. The experiments demonstrate that a single treatment at adult age can provoke imprinting, which alters - in the present case - the serotonin and histamine content of immune cells durably.",
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AU - Kovács, P.

AU - Pállinger, E.

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N2 - Hormonal imprinting was provoked by serotonin treatment in adult age. Three weeks after treatment with 100 μg serotonin, the serotonin and histamine content of peritoneal cells (mast cells, lymphocytes and the monocyte-macrophage-granulocyte group), white blood cells (lymphocytes, granulocytes and monocytes) and thymic lymphocytes was studied by flow cytometry. The content of both amines was significantly higher in the mast cells of males and lower in females. Blood lymphocytes contained a higher serotonin and histamine level in males, and a lower serotonin level in females. The peritoneal monocyte-macrophage-granulocyte group contained less serotonin in both males and females. Thymocytes contained higher levels of both amines in females and higher histamine level in males. The experiments demonstrate that a single treatment at adult age can provoke imprinting, which alters - in the present case - the serotonin and histamine content of immune cells durably.

AB - Hormonal imprinting was provoked by serotonin treatment in adult age. Three weeks after treatment with 100 μg serotonin, the serotonin and histamine content of peritoneal cells (mast cells, lymphocytes and the monocyte-macrophage-granulocyte group), white blood cells (lymphocytes, granulocytes and monocytes) and thymic lymphocytes was studied by flow cytometry. The content of both amines was significantly higher in the mast cells of males and lower in females. Blood lymphocytes contained a higher serotonin and histamine level in males, and a lower serotonin level in females. The peritoneal monocyte-macrophage-granulocyte group contained less serotonin in both males and females. Thymocytes contained higher levels of both amines in females and higher histamine level in males. The experiments demonstrate that a single treatment at adult age can provoke imprinting, which alters - in the present case - the serotonin and histamine content of immune cells durably.

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