Prolongation of the QTc-interval reflects the severity of autonomic neuropathy in primary biliary cirrhosis and in other non-alcoholic liver diseases.

P. Kempler, F. Szalay, A. Váradi, K. Keresztes, E. Kádár, E. Tánczos, J. Petrik

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

It was the aim of our study to prove a potential correlation (a) between laboratory findings of cholestasis and autonomic neuropathy (AN) and (b) between the severity of AN and the prolongation of the corrected QT-time (QTc). The five standard tests of autonomic cardiac neuropathy were investigated. QTc was calculated according to Bazett's formula. 12 out of 14 patients with primary biliary cirrhosis, 18 out of 21 patients with HBsAg positive liver diseases and 11 out of 14 patients with cirrhosis of other origin had AN. No significant correlation between the laboratory parameters of cholestasis and AN was found. Abnormal QTc values (> 440 m/sec) were observed significantly more often (p < 0.002) in patients with AN than in patients without AN. Significant linear regression (p < 0.01) could be confirmed between the prolongation of the QTc-time and the severity of AN. Besides the non-invasive investigation of the cardiovascular reflexes the evaluation of the QT-time might be an additional diagnostic means to identify patients with an increased cardiovascular risk in chronic non-alcoholic liver diseases.

Original languageEnglish
Pages (from-to)96-98
Number of pages3
JournalZeitschrift für Gastroenterologie
Volume31 Suppl 2
Publication statusPublished - Feb 1993

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Prolongation of the QTc-interval reflects the severity of autonomic neuropathy in primary biliary cirrhosis and in other non-alcoholic liver diseases.'. Together they form a unique fingerprint.

  • Cite this