Prolactin response to immobilization stress and hemorrhage

The effect of hypothalamic deafferentations and posterior pituitary denervation

J. Jurcovicová, R. Kvetnansky, M. Dobrakovová, D. Jezová, A. Kiss, G. Makara

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The roles of posterior and anterolateral connections to the mediobasal hypothalamus (MBH) as well as innervation of the posterior pituitary in the PRL response to immobilization (IMO) and hemorrhage (HEM) were studied by means of surgical isolation, performed 6-9 days before stress exposure. Male rats bearing indwelling tail artery cannulae subjected to 120-min IMO reached peak PRL secretion in 5-20 min. HEM of 25% elicited a significant rise of PRL levels. A posterior cut in the MBH, performed without damaging the serotonergic fibers from the brain stem, attenuated the PRL response to 25% HEM, whereas the PRL elevation due to IMO remained unaffected. An anterolateral cut around the MBH eliminated both the IMO-and HEM-induced stimulation of PRL. Posterior lobe denervation reduced by about 27% the PRL response to IMO and eliminated the response to HEM. These results suggest the following conclusions. The neural structures located posteriorly to the MBH are involved in the transfer of signals triggering PRL secretion due to hypovolemia. Intact anterolateral pathways to the MBH and stalk-median eminence region are essential for the PRL-releasing activity under both stimuli. The posterior lobe may be an important link in the PRL stress response in male rats.

Original languageEnglish
Pages (from-to)2527-2533
Number of pages7
JournalEndocrinology
Volume126
Issue number5
Publication statusPublished - May 1990

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Denervation
Immobilization
Prolactin
Hypothalamus
Hemorrhage
Median Eminence
Hypovolemia
Brain Stem
Tail
Arteries

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Prolactin response to immobilization stress and hemorrhage : The effect of hypothalamic deafferentations and posterior pituitary denervation. / Jurcovicová, J.; Kvetnansky, R.; Dobrakovová, M.; Jezová, D.; Kiss, A.; Makara, G.

In: Endocrinology, Vol. 126, No. 5, 05.1990, p. 2527-2533.

Research output: Contribution to journalArticle

Jurcovicová, J, Kvetnansky, R, Dobrakovová, M, Jezová, D, Kiss, A & Makara, G 1990, 'Prolactin response to immobilization stress and hemorrhage: The effect of hypothalamic deafferentations and posterior pituitary denervation', Endocrinology, vol. 126, no. 5, pp. 2527-2533.
Jurcovicová, J. ; Kvetnansky, R. ; Dobrakovová, M. ; Jezová, D. ; Kiss, A. ; Makara, G. / Prolactin response to immobilization stress and hemorrhage : The effect of hypothalamic deafferentations and posterior pituitary denervation. In: Endocrinology. 1990 ; Vol. 126, No. 5. pp. 2527-2533.
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