Prolactin release induced by opiate agonists, effect of glucocorticoid pretreatment in intact and adrenalectomized rats

D. T. Kiem, B. Kanyicska, E. Stark, M. I.K. Fekete

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cortisol administered at a dose of 25 mg/kg 24 h before measurements decreased the prolactin secretion induced by intraventricularly given opioids (dynorphin, beta-endorphin, Met-enkephalin or D-Met-Pro-enkephalinamide). The effect of cortisol was depressed by actinomycin D pretreatment. The cortisol-induced inhibition of the action of morphine was facilitated in adrenalectomized animals; measuring the effects of increasing doses of cortisol a maximal inhibition was obtained at a dose of 5 mg/kg. The opioid-induced corticosterone secretion was not affected 24 h after a single administration of cortisol. The present results show that the cortisol-induced inhibition of opioid-induced prolactin secretion is dependent on protein synthesis and independent of changes in drug metabolism, and of the type of opiate receptor preferentially affected by the opiate agonists employed.

Original languageEnglish
Pages (from-to)174-179
Number of pages6
JournalNeuroendocrinology
Volume48
Issue number2
DOIs
Publication statusPublished - Jan 1 1988

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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