Progressive systemic sclerosis-from the molecular background to innovative therapies

Peter Szodoray, Emese Kiss

Research output: Contribution to journalReview article

1 Citation (Scopus)


Systemic sclerosis (SSc) is a complex autoimmune disorder. The cornerstones of the pathogenesis are vascular damage, fibrogenesis and various cellular and humoral autoimmune processes. The aim of the present review is to describe pathogenic steps, leading to the hallmark clinical picture of SSc. Indeed, numerous therapeutical approaches have been tested/are in use, directed towards vascular damage, fibrogenesis, as well as autoimmune processes in order to decelerate the progression of the disease. These therapies are also discussed in the review. Finally, we described certain novel immune-modulating possibilities, namely autologous stemcell transplantation and extracorporeal photochemotherapy.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number2
Publication statusPublished - Jan 1 2010


  • Pathogenesis
  • Review
  • Systemic sclerosis
  • Therapeutical possibilities

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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