Progresszív multifokális leukoencephalopathia.

Translated title of the contribution: Progressive multifocal leukoencephalopathy

Endre Pál, Zsuzsanna Aschermann, Eva Gömöri, Gábor Géza Kovács, Gábor Simon, László Maródi, Sámuel Komoly, Zsolt Illés

Research output: Contribution to journalArticle

2 Citations (Scopus)


Progressive multifocal leukoencephalopathy is a rare disease caused by the reactivation of an opportunistic agent, JC virus almost in every cases in immunodeficient conditions. The disease is characterized by multifocal demyelinating lesions of the central nervous system and causes death within a few months. The authors report two patients: a 67 year-old male treated because of chronic lymphoid leukemia, and a 19 year-old male having a hereditary immunodeficiency, X-linked hyper IgM syndrome. In both cases continuously progressive right, later both hemispheric signs were detected. Cerebrospinal fluid was not helpful. Brain MRI showed bilateral large, white matter lesion. The progression was not influenced by the treatment, finally both patient died ten and six weeks after the appearance of first complaints. The diagnosis was confirmed by brain biopsy and autopsy in both cases. Our cases demonstrate that progressive multifocal leukoencephalopathy can develop in various immunodeficiencies.

Translated title of the contributionProgressive multifocal leukoencephalopathy
Original languageHungarian
Pages (from-to)263-268
Number of pages6
JournalIdeggyógyászati szemle
Issue number5-6
Publication statusPublished - May 30 2007

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Pál, E., Aschermann, Z., Gömöri, E., Kovács, G. G., Simon, G., Maródi, L., Komoly, S., & Illés, Z. (2007). Progresszív multifokális leukoencephalopathia. Ideggyógyászati szemle, 60(5-6), 263-268.