Prognostic value of interim and restaging PET/CT in Hodgkin lymphoma. Results of the CHEAP (Chemotherapy Effectiveness Assessment by PET/CT) study – Long term observation

Z. Miltenyi, S. Barna, I. Garai, Z. Simon, A. Jona, F. Magyari, M. Gergely, Z. Nagy, K. Keresztes, P. Pettendi, A. Illés

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Very few studies have determined the prognostic value of interim and restaging PET/CT in patients with Hodgkin lymphoma using current standard of care therapy outside clinical trials. We analyzed the effect of the results of interim and restaging PET/CT on the survival (overall- and relapse-free) in patients who received standard first-line treatment based on the stage of disease and risk factors. We investigated the differences between the relapse and non-relapse groups based on the clinical pathological characteristics of patients who had positive interim PET/CT results. Between January 1, 2007 and December 31, 2011, the staging, interim and restaging PET/CT scans of patients with Hodgkin lymphoma were analyzed. The Deauville criteria were used for the evaluation of interim PET/CT scans. One hundred and thirteen Hodgkin lymphoma patients underwent staging, interim and restaging PET/CT scans. None of the therapy was modified based on the interim PET/CT results. The median follow-up time was 43.5 months. A total of 62 early stage patients and 51 advanced stage patients were identified. The five-year overall survival rates were 93.4% in the interim PET negative group and 58% in the interim PET positive group (p

Original languageEnglish
Pages (from-to)627-634
Number of pages8
JournalNeoplasma
Volume62
Issue number4
DOIs
Publication statusPublished - 2015

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Hodgkin Disease
Observation
Drug Therapy
Recurrence
Standard of Care
Therapeutics
Survival Rate
Clinical Trials
Survival
Positron Emission Tomography Computed Tomography

Keywords

  • Hodgkin lymphoma
  • PET/CT
  • Predictive value

ASJC Scopus subject areas

  • Cancer Research

Cite this

Prognostic value of interim and restaging PET/CT in Hodgkin lymphoma. Results of the CHEAP (Chemotherapy Effectiveness Assessment by PET/CT) study – Long term observation. / Miltenyi, Z.; Barna, S.; Garai, I.; Simon, Z.; Jona, A.; Magyari, F.; Gergely, M.; Nagy, Z.; Keresztes, K.; Pettendi, P.; Illés, A.

In: Neoplasma, Vol. 62, No. 4, 2015, p. 627-634.

Research output: Contribution to journalArticle

Miltenyi, Z. ; Barna, S. ; Garai, I. ; Simon, Z. ; Jona, A. ; Magyari, F. ; Gergely, M. ; Nagy, Z. ; Keresztes, K. ; Pettendi, P. ; Illés, A. / Prognostic value of interim and restaging PET/CT in Hodgkin lymphoma. Results of the CHEAP (Chemotherapy Effectiveness Assessment by PET/CT) study – Long term observation. In: Neoplasma. 2015 ; Vol. 62, No. 4. pp. 627-634.
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