Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors

Judit Kralovánszky, I. Köves, Zsolt Orosz, Csilla Katona, Katalin Tóth, Pál Rahóty, Ferenc Czeglédi, Tibor Kovács, Barna Budai, Lehel Hullán, A. Jeney

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The aim of the present study was to determine the relative intratumoral activity of two pyrimidine biosynthetic enzymes, i.e. thymidylate synthase (TS) and thymidine kinase (TK), in human colorectal cancers to compare their possible relationship with demographic and pathologic characteristics of the patients and their tumors, and moreover to evaluate their predictive significance regarding 5-fluorouracil (5-FU) sensitivity and the overall survival of patients, respectively. TS and TK levels were significantly increased in the tumor compared to peritumoral tissue. However, no significant relationship between TS/TK activity and demographic features of the patients or pathologic characteristics of their tumors could be demonstrated. Kaplan-Meier analysis showed that the overall survival of patients with low TS activity was significantly longer (p <0.012) compared to those with high TS activity. Such a difference could not be demonstrated between patients with high or low TK activity; however, combined evaluation of the two parameters proved that TK may contribute to the more precise assessment of disease prognosis, and it may further influence treatment decisions, i.e. the selection of patients for adjuvant therapy with 5-FU and folinic acid. Multivariate analysis showed that among the variables tested, beside Dukes' stage, TS and TK activities were significant prognostic factors for the overall survival of colorectal cancer patients.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalOncology
Volume62
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

Thymidylate Synthase
Thymidine Kinase
dTMP kinase
Colorectal Neoplasms
Enzymes
Fluorouracil
Survival
Demography
Neoplasms
Leucovorin
Kaplan-Meier Estimate
Patient Selection
Multivariate Analysis
Therapeutics

Keywords

  • Colorectal cancer
  • Prognosis
  • Thymidine kinase
  • Thymidylate synthase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors. / Kralovánszky, Judit; Köves, I.; Orosz, Zsolt; Katona, Csilla; Tóth, Katalin; Rahóty, Pál; Czeglédi, Ferenc; Kovács, Tibor; Budai, Barna; Hullán, Lehel; Jeney, A.

In: Oncology, Vol. 62, No. 2, 2002, p. 167-174.

Research output: Contribution to journalArticle

Kralovánszky, J, Köves, I, Orosz, Z, Katona, C, Tóth, K, Rahóty, P, Czeglédi, F, Kovács, T, Budai, B, Hullán, L & Jeney, A 2002, 'Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors', Oncology, vol. 62, no. 2, pp. 167-174. https://doi.org/10.1159/000048263
Kralovánszky, Judit ; Köves, I. ; Orosz, Zsolt ; Katona, Csilla ; Tóth, Katalin ; Rahóty, Pál ; Czeglédi, Ferenc ; Kovács, Tibor ; Budai, Barna ; Hullán, Lehel ; Jeney, A. / Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors. In: Oncology. 2002 ; Vol. 62, No. 2. pp. 167-174.
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