Prognostic significance of microvascularization in cases of operated lung cancer

Tamas Szöke, Klaus Kayser, Jan Dirk Baumhäkel, Imre Trojan, Jozsef Furak, L. Tiszlavicz, Jozsef Eller, K. Boda

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Measurement of microvascularization and determination of its prognostic significance in cases of lung cancer. Methods: Section prepared from histological material from 432 radically operated non-small cell lung cancer patients were stained with antibodies against factor VIII-associated antigen. During computer imaging, the absolute and relative parameters of the vascularization were determined, as was the density of tumour cells situated in the vicinity of the vessels. The results were compared with the TNM status, the cell type and the survival. Results: Each parameter demonstrated an enhanced vascularization in classifications T2 and T4, but only the surface fraction, the mean vascular circumference and the mean vascular area displayed a significant change. The microvascularization parameters did not differ significantly between with different N status, however, the cell density progressively increased in the areas close to the vessels in advanced pN classifications. Elevation of the tumour cell density within 20 μm distance of the vessels was accompanied by a significantly poorer survival rate. The density of tumour cells within 20 μm region was the second strongest prognostic factor after the N status. Conclusions: More advanced tumour classifications grow with enhanced vascularization. A clear-cut connection cannot be demonstrated between the vascularization and appearance of lymph node metastases. The density of tumour cells measured in the direct vicinity of vessels is an important prognostic factor.

Original languageEnglish
Pages (from-to)1106-1111
Number of pages6
JournalEuropean Journal of Cardio-thoracic Surgery
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 2005

Fingerprint

Lung Neoplasms
Cell Count
Neoplasms
Blood Vessels
Factor VIII
Non-Small Cell Lung Carcinoma
Cell Survival
Survival Rate
Lymph Nodes
Neoplasm Metastasis
Antigens
Antibodies

Keywords

  • Angiogenesis
  • Lung cancer
  • Survival
  • Syntactic structure analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Prognostic significance of microvascularization in cases of operated lung cancer. / Szöke, Tamas; Kayser, Klaus; Baumhäkel, Jan Dirk; Trojan, Imre; Furak, Jozsef; Tiszlavicz, L.; Eller, Jozsef; Boda, K.

In: European Journal of Cardio-thoracic Surgery, Vol. 27, No. 6, 06.2005, p. 1106-1111.

Research output: Contribution to journalArticle

Szöke, Tamas ; Kayser, Klaus ; Baumhäkel, Jan Dirk ; Trojan, Imre ; Furak, Jozsef ; Tiszlavicz, L. ; Eller, Jozsef ; Boda, K. / Prognostic significance of microvascularization in cases of operated lung cancer. In: European Journal of Cardio-thoracic Surgery. 2005 ; Vol. 27, No. 6. pp. 1106-1111.
@article{39c9ece119c24f078ff0eee6d38d5b4b,
title = "Prognostic significance of microvascularization in cases of operated lung cancer",
abstract = "Objective: Measurement of microvascularization and determination of its prognostic significance in cases of lung cancer. Methods: Section prepared from histological material from 432 radically operated non-small cell lung cancer patients were stained with antibodies against factor VIII-associated antigen. During computer imaging, the absolute and relative parameters of the vascularization were determined, as was the density of tumour cells situated in the vicinity of the vessels. The results were compared with the TNM status, the cell type and the survival. Results: Each parameter demonstrated an enhanced vascularization in classifications T2 and T4, but only the surface fraction, the mean vascular circumference and the mean vascular area displayed a significant change. The microvascularization parameters did not differ significantly between with different N status, however, the cell density progressively increased in the areas close to the vessels in advanced pN classifications. Elevation of the tumour cell density within 20 μm distance of the vessels was accompanied by a significantly poorer survival rate. The density of tumour cells within 20 μm region was the second strongest prognostic factor after the N status. Conclusions: More advanced tumour classifications grow with enhanced vascularization. A clear-cut connection cannot be demonstrated between the vascularization and appearance of lymph node metastases. The density of tumour cells measured in the direct vicinity of vessels is an important prognostic factor.",
keywords = "Angiogenesis, Lung cancer, Survival, Syntactic structure analysis",
author = "Tamas Sz{\"o}ke and Klaus Kayser and Baumh{\"a}kel, {Jan Dirk} and Imre Trojan and Jozsef Furak and L. Tiszlavicz and Jozsef Eller and K. Boda",
year = "2005",
month = "6",
doi = "10.1016/j.ejcts.2005.01.036",
language = "English",
volume = "27",
pages = "1106--1111",
journal = "European Journal of Cardio-thoracic Surgery",
issn = "1010-7940",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Prognostic significance of microvascularization in cases of operated lung cancer

AU - Szöke, Tamas

AU - Kayser, Klaus

AU - Baumhäkel, Jan Dirk

AU - Trojan, Imre

AU - Furak, Jozsef

AU - Tiszlavicz, L.

AU - Eller, Jozsef

AU - Boda, K.

PY - 2005/6

Y1 - 2005/6

N2 - Objective: Measurement of microvascularization and determination of its prognostic significance in cases of lung cancer. Methods: Section prepared from histological material from 432 radically operated non-small cell lung cancer patients were stained with antibodies against factor VIII-associated antigen. During computer imaging, the absolute and relative parameters of the vascularization were determined, as was the density of tumour cells situated in the vicinity of the vessels. The results were compared with the TNM status, the cell type and the survival. Results: Each parameter demonstrated an enhanced vascularization in classifications T2 and T4, but only the surface fraction, the mean vascular circumference and the mean vascular area displayed a significant change. The microvascularization parameters did not differ significantly between with different N status, however, the cell density progressively increased in the areas close to the vessels in advanced pN classifications. Elevation of the tumour cell density within 20 μm distance of the vessels was accompanied by a significantly poorer survival rate. The density of tumour cells within 20 μm region was the second strongest prognostic factor after the N status. Conclusions: More advanced tumour classifications grow with enhanced vascularization. A clear-cut connection cannot be demonstrated between the vascularization and appearance of lymph node metastases. The density of tumour cells measured in the direct vicinity of vessels is an important prognostic factor.

AB - Objective: Measurement of microvascularization and determination of its prognostic significance in cases of lung cancer. Methods: Section prepared from histological material from 432 radically operated non-small cell lung cancer patients were stained with antibodies against factor VIII-associated antigen. During computer imaging, the absolute and relative parameters of the vascularization were determined, as was the density of tumour cells situated in the vicinity of the vessels. The results were compared with the TNM status, the cell type and the survival. Results: Each parameter demonstrated an enhanced vascularization in classifications T2 and T4, but only the surface fraction, the mean vascular circumference and the mean vascular area displayed a significant change. The microvascularization parameters did not differ significantly between with different N status, however, the cell density progressively increased in the areas close to the vessels in advanced pN classifications. Elevation of the tumour cell density within 20 μm distance of the vessels was accompanied by a significantly poorer survival rate. The density of tumour cells within 20 μm region was the second strongest prognostic factor after the N status. Conclusions: More advanced tumour classifications grow with enhanced vascularization. A clear-cut connection cannot be demonstrated between the vascularization and appearance of lymph node metastases. The density of tumour cells measured in the direct vicinity of vessels is an important prognostic factor.

KW - Angiogenesis

KW - Lung cancer

KW - Survival

KW - Syntactic structure analysis

UR - http://www.scopus.com/inward/record.url?scp=19344366516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19344366516&partnerID=8YFLogxK

U2 - 10.1016/j.ejcts.2005.01.036

DO - 10.1016/j.ejcts.2005.01.036

M3 - Article

VL - 27

SP - 1106

EP - 1111

JO - European Journal of Cardio-thoracic Surgery

JF - European Journal of Cardio-thoracic Surgery

SN - 1010-7940

IS - 6

ER -