Prognostic role of aortic atherosclerosis and coronary flow reserve in patients with suspected coronary artery disease

Attila Nemes, T. Forster, Marcel L. Geleijnse, Osama I I Soliman, Folkert J ten Cate, M. Csanády

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The degree of aortic atherosclerosis (AA) and coronary flow reserve (CFR) can be evaluated simultaneously during the same transoesophageal echocardiographic (TEE) examination. The aim of the present study was to assess the relative prognostic value of simultaneously evaluated CFR and AA by TEE in patients with suspected or known coronary artery disease (CAD). Methods: The present study comprised 397 inhospital patients with chest pain. All patients underwent a transthoracic echocardiographic study to evaluate left ventricular function and a vasodilator TEE study to evaluate simultaneously CFR and the degree of AA. Results: Coronary angiography was performed in 292 patients (74%). Significant CAD was less frequent in patients with normal CFR and low-grade AA. During a mean follow-up of 41 ± 12 months, 23 patients suffered cardiovascular death (14 sudden cardiac death, 7 heart failure, 2 cardiovascular thrombosis). Univariate analysis yielded age, diabetes, AA grade and CFR as predictors of survival. Multivariate regression analysis showed that only CFR (hazard ratio (HR) 2.9, P <0.02) and diabetes (HR 3.8, P <0.01) were independent predictors of survival. Conclusions: It can be said that both CFR and AA grade are associated with poor survival but only CFR is an independent predictor.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalInternational Journal of Cardiology
Volume131
Issue number1
DOIs
Publication statusPublished - Dec 17 2008

Fingerprint

Coronary Artery Disease
Atherosclerosis
Survival
Sudden Cardiac Death
Coronary Angiography
Chest Pain
Vasodilator Agents
Left Ventricular Function
Thrombosis
Multivariate Analysis
Heart Failure
Regression Analysis

Keywords

  • Aortic atherosclerosis
  • Coronary flow reserve
  • Echocardiography
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prognostic role of aortic atherosclerosis and coronary flow reserve in patients with suspected coronary artery disease. / Nemes, Attila; Forster, T.; Geleijnse, Marcel L.; Soliman, Osama I I; Cate, Folkert J ten; Csanády, M.

In: International Journal of Cardiology, Vol. 131, No. 1, 17.12.2008, p. 45-50.

Research output: Contribution to journalArticle

Nemes, Attila ; Forster, T. ; Geleijnse, Marcel L. ; Soliman, Osama I I ; Cate, Folkert J ten ; Csanády, M. / Prognostic role of aortic atherosclerosis and coronary flow reserve in patients with suspected coronary artery disease. In: International Journal of Cardiology. 2008 ; Vol. 131, No. 1. pp. 45-50.
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