Prognostic relevance of the expressions of CAV1 and TES genes on 7q31 in melanoma

Laura Vizkeleti, Szilvia Ecsedi, Zsuzsa Rakosy, Agnes Begany, Gabriella Emri, Reka Toth, Adrienn Orosz, Attila Gabor Szollosi, Gabor Mehes, Roza Adany, Margit Balazs

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3 Citations (Scopus)

Abstract

The 7q31 locus contains several genes affected in cancer progression. Although evidences exist regarding its impact on tumorigenesis, the role of genetic alterations and the expressions of locus-related genes are still controversial. Our study aimed to define the 7q31 copy number alterations in primary melanomas, primarymetastatic tumor pairs and cell lines. Data were correlated with clinical-pathological parameters. Genetic data show that 7q31 copy number distribution was heterogeneous in both primary and metastatic tumors. Extra copies were highly accompanied by chromosome 7 polisomy, and significantly increased in primary lesions with poor prognosis. Additionally, we determined the mRNA and protein levels of the locus-related CAV1 and TES genes. TES mRNA level was associated with metastatic location. CAV1 mRNA and protein levels were significantly higher in thicker tumors, however, lack of protein was also observed in a subpopulation of thin lesions. Expressions of CAV1 and TES were not associated with 7q31 alterations. In conclusion, 7q31 amplification can predict unfavorable outcome. Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion.

Original languageEnglish
Pages (from-to)1802-1812
Number of pages11
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number5
Publication statusPublished - Jan 1 2012

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Keywords

  • 7q31
  • Caveolin 1
  • Fluorescence In Situ hybridization
  • Malignant melanoma
  • Testin
  • Tissue microarray

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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