Prognostic histological and immune markers of renal cell carcinoma

Tamás Magyarlaki, István Busogány, László Kaiser, Farkas Sükösd, Róbert Döbrönte, Barbara Simon, Attila Fazekas, Judit Nagy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recent development on the fields of molecular genetics and immunology of human renal cell carcinoma (RCC) have resulted in more successful treatment of advanced and metastatic RCCs. Reevaluation of the prognostic/predictive data aim the initial tumor staging of RCC patients to achieve better patient selection for immune and gene therapy. 125 RCC patients diagnosed according to the Heidelberg histological classification, graded, Robson staged, immune treated (Interferon-α + Vinblastin or Broncho-Waxom/Decaris) were followed-up clinically for 36 months. Tumor immunity markers by immunohistochemistry of tumor infiltrating lymphocytes (TIL) were detected by immunoperoxidase methods using monoclonal antibodies. Tumoral immune complexes (TIC) were visualized by fluorescent polyclonal antibodies. Histologically oncocytomas defined a better (p<0.02) and sarcomatous RCCs a worse (p<0.01) follow-up prognosis. Basically, the metastatic status (related with the stage and grade) determined the clinical outcome (p<0.00002) of the RCC patients. Tumoral immune complexes (TIC) were weak positive, while tumor infiltrating lymphocytes (TIL) weak negative predictors of the succes of Broncho-Waxom/Decaris immune therapy. Molecular genetic based histological classification, grade, stage and metastatic status parameters together with some tumor immunity parameters (TIL, TIC) can predict the success of immunotherapy of RCC patients.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalPathology and Oncology Research
Volume7
Issue number2
DOIs
Publication statusPublished - Jan 1 2001

Keywords

  • Clinicopathology
  • Histology
  • Immunohistochemistry
  • Immunotherapy
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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  • Cite this

    Magyarlaki, T., Busogány, I., Kaiser, L., Sükösd, F., Döbrönte, R., Simon, B., Fazekas, A., & Nagy, J. (2001). Prognostic histological and immune markers of renal cell carcinoma. Pathology and Oncology Research, 7(2), 118-124. https://doi.org/10.1007/BF03032577