Prognosis of acute myeloid leukemia transformed from myelodysplastic syndromes: A multicenter retrospective study

Namiko Okuyama, Wolfgang R. Sperr, Katalin Kadar, Sietske Bakker, Gergely Szombath, Hiroshi Handa, Hideto Tamura, Asaka Kondo, Peter Valent, Judit Várkonyi, Arjan van de Loosdrecht, Kiyoyuki Ogata

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Myelodysplastic syndromes (MDS) often transform into acute leukemia (AL-MDS), although its prognostic details have not been examined thoroughly. We retrospectively analyzed the prognosis of 189 AL-MDS patients. Ninety-four patients received best supportive care (BSC), and 94 patients received disease-modifying therapies (DMT) that included chemotherapy (CHT) for 65 patients, allogeneic stem-cell transplantation (allo-SCT) for 21 patients, and other therapies for 8 patients. The median survival time was 142 days. In patients treated with BSC, platelet count alone was an independent prognostic factor. In younger patients treated with DMT (<60 years, N=25), allo-SCT was an independent prognostic factor associated with longer survival. In older patients treated with DMT (≥60 years, N=69), the therapy type did not affect survival, and performance status and MDS-specific comorbidity index were independent prognostic factors.

Original languageEnglish
Pages (from-to)862-867
Number of pages6
JournalLeukemia Research
Volume37
Issue number8
DOIs
Publication statusPublished - Aug 1 2013

    Fingerprint

Keywords

  • Acute myeloid leukemia
  • Allogeneic transplantation
  • Myelodysplastic syndromes
  • Performance status
  • Prognosis
  • Therapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Okuyama, N., Sperr, W. R., Kadar, K., Bakker, S., Szombath, G., Handa, H., Tamura, H., Kondo, A., Valent, P., Várkonyi, J., van de Loosdrecht, A., & Ogata, K. (2013). Prognosis of acute myeloid leukemia transformed from myelodysplastic syndromes: A multicenter retrospective study. Leukemia Research, 37(8), 862-867. https://doi.org/10.1016/j.leukres.2013.02.018