Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio

Zoltán Locsei, Dóra Horváth, K. Rácz, I. Szabolcs, G. Kovács, Erzsébet Toldy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: Estrogens in oral contraceptives (OC) may influence plasma aldosterone/plasma renin activity (ALD/PRA) and plasma aldosterone/plasma renin concentration (ALD/DRC) ratios, but the effect of progestins on these ratios has not been sufficiently studied so far. Design and methods: PRA (RIA, DiaSorin), DRC and ALD (IRMA, RIA, Beckman Coulter) were measured, then ALD/PRA and ALD/DRC were calculated in 86 healthy normotensive women (aged 27.3. ±. 7.5. years), 63 using progestin-containing OC: either gestodene (GTD, n = 25), desogestrel (DSG, n = 22) or drospirenone (DRSP, n = 16). 23 OC-nonusers served as control. Results: Data are presented as median and lower and upper quartiles. PRA, DRC and ALD levels were higher (p.

Original languageEnglish
Pages (from-to)1516-1518
Number of pages3
JournalClinical Biochemistry
Volume45
Issue number16-17
DOIs
Publication statusPublished - Nov 2012

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Progestins
Oral Contraceptives
Aldosterone
Renin
Plasmas
Desogestrel
Estrogens
Thermodynamic properties

Keywords

  • Aldosterone/plasma renin activity ratio
  • Aldosterone/plasma renin concentration ratio
  • Oral contraceptives
  • Progestin

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio. / Locsei, Zoltán; Horváth, Dóra; Rácz, K.; Szabolcs, I.; Kovács, G.; Toldy, Erzsébet.

In: Clinical Biochemistry, Vol. 45, No. 16-17, 11.2012, p. 1516-1518.

Research output: Contribution to journalArticle

Locsei, Zoltán ; Horváth, Dóra ; Rácz, K. ; Szabolcs, I. ; Kovács, G. ; Toldy, Erzsébet. / Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio. In: Clinical Biochemistry. 2012 ; Vol. 45, No. 16-17. pp. 1516-1518.
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