Progesterone Suppression of Pregnancy Lymphocytes Is not Mediated by Glucocorticoid Effect

JULIA SZEKERES‐BARTHO, D. PHILIBERT, G. CHAOUAT

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Abstract

ABSTRACT: This study investigated whether the suppressive effect of progesterone on pregnancy lymphocytes is mediated by specific progesterone receptors. The effects of a competitive progesterone antagonist (RU486) and a specific glucocorticoid receptor blocker (RU43044) were tested on the release of a blocking factor by progesterone‐treated pregnancy lymphocytes. RU 486 tested at an equal concentration as progesterone significantly inhibited the production of the blocking factor, while RU 43044 was without effect. These data suggest that in pregnancy, lymphocyte progesterone acts on specific progesterone receptors and glucocorticoid binding sites are not involved. 1990 Munksgaard

Original languageEnglish
Pages (from-to)42-43
Number of pages2
JournalAmerican Journal of Reproductive Immunology
Volume23
Issue number2
DOIs
Publication statusPublished - Jun 1990

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Keywords

  • glucocorticoid receptors
  • lymphocytes
  • progesterone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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