Progesterone as an immunomodulatory molecule

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Increased progesterone sensitivity of pregnancy lymphocytes is due to activation-induced appearance of progesterone binding sites in the lymphocytes. Following recognition of fetally derived antigens γ/δ TCR+ cells develop progesterone receptors. Progesterone binding results in the synthesis of a mediator protein named the progesterone-induced blocking factor (PIBF). PIBF by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

Original languageEnglish
Pages (from-to)1037-1048
Number of pages12
JournalInternational Immunopharmacology
Issue number6
Publication statusPublished - Jun 1 2001


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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