Production of meloxicam suspension using pulsed laser ablation in liquid (PLAL) technique

B. Hopp, Eszter Nagy, Franciska Peták, T. Smausz, Judit Kopniczky, Csaba Tápai, Judit Budai, Ibolya Zita Papp, Á. Kukovecz, Rita Ambrus, P. Szabó-Révész

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Organic particles in the micrometer/nanometer size range can find applications in various fields. Unfortunately their production is not a straightforward task for a number of materials. In the present work the production of meloxicam particles in the micrometer range was aimed with the help of pulsed laser ablation in liquid environment (PLAL). Targets pressed from crystalline meloxicam powder were placed in distilled water and irradiated with a focused beam of a frequency doubled (532 nm) nanosecond Nd:YAG laser at 4.2-9.4 J cm-2 fluence. Morphological investigation showed that the produced suspension contained particles in the ∼100 nm to 10 μm size range (1.0-2.0 μm on average), which is about 10 times smaller than the size of the initial material. FTIR spectroscopic investigations demonstrated that the chemical composition was preserved, while x-ray diffraction and calorimetric measurements indicated partial amorphization of meloxicam during the process. The overall results suggest that the particles are mostly produced by the fragmentation of the pressed target by the recoil forces induced by the laser pulse. Long period sedimentation tests of the suspension combined with UV-vis spectroscopic analysis showed that by the method of PLAL a greater fraction of the poorly water soluble meloxicam could be dispersed and dissolved in water in a pharmaceutically preferred formation than by simple dissolution of it.

Original languageEnglish
Article number165401
JournalJournal of Physics D: Applied Physics
Volume51
Issue number16
DOIs
Publication statusPublished - Mar 28 2018

Fingerprint

meloxicam
Laser ablation
Pulsed lasers
laser ablation
pulsed lasers
Suspensions
Liquids
liquids
Water
micrometers
Spectroscopic analysis
Amorphization
water
Sedimentation
Laser pulses
spectroscopic analysis
Dissolution
Diffraction
Powders
Crystalline materials

Keywords

  • laser ablation
  • laser fragmentation
  • meloxicam
  • particle-size reduction
  • suspension

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Acoustics and Ultrasonics
  • Surfaces, Coatings and Films

Cite this

Production of meloxicam suspension using pulsed laser ablation in liquid (PLAL) technique. / Hopp, B.; Nagy, Eszter; Peták, Franciska; Smausz, T.; Kopniczky, Judit; Tápai, Csaba; Budai, Judit; Papp, Ibolya Zita; Kukovecz, Á.; Ambrus, Rita; Szabó-Révész, P.

In: Journal of Physics D: Applied Physics, Vol. 51, No. 16, 165401, 28.03.2018.

Research output: Contribution to journalArticle

Hopp, B. ; Nagy, Eszter ; Peták, Franciska ; Smausz, T. ; Kopniczky, Judit ; Tápai, Csaba ; Budai, Judit ; Papp, Ibolya Zita ; Kukovecz, Á. ; Ambrus, Rita ; Szabó-Révész, P. / Production of meloxicam suspension using pulsed laser ablation in liquid (PLAL) technique. In: Journal of Physics D: Applied Physics. 2018 ; Vol. 51, No. 16.
@article{765774e8656f4ca5b747bdd9375d9c7e,
title = "Production of meloxicam suspension using pulsed laser ablation in liquid (PLAL) technique",
abstract = "Organic particles in the micrometer/nanometer size range can find applications in various fields. Unfortunately their production is not a straightforward task for a number of materials. In the present work the production of meloxicam particles in the micrometer range was aimed with the help of pulsed laser ablation in liquid environment (PLAL). Targets pressed from crystalline meloxicam powder were placed in distilled water and irradiated with a focused beam of a frequency doubled (532 nm) nanosecond Nd:YAG laser at 4.2-9.4 J cm-2 fluence. Morphological investigation showed that the produced suspension contained particles in the ∼100 nm to 10 μm size range (1.0-2.0 μm on average), which is about 10 times smaller than the size of the initial material. FTIR spectroscopic investigations demonstrated that the chemical composition was preserved, while x-ray diffraction and calorimetric measurements indicated partial amorphization of meloxicam during the process. The overall results suggest that the particles are mostly produced by the fragmentation of the pressed target by the recoil forces induced by the laser pulse. Long period sedimentation tests of the suspension combined with UV-vis spectroscopic analysis showed that by the method of PLAL a greater fraction of the poorly water soluble meloxicam could be dispersed and dissolved in water in a pharmaceutically preferred formation than by simple dissolution of it.",
keywords = "laser ablation, laser fragmentation, meloxicam, particle-size reduction, suspension",
author = "B. Hopp and Eszter Nagy and Franciska Pet{\'a}k and T. Smausz and Judit Kopniczky and Csaba T{\'a}pai and Judit Budai and Papp, {Ibolya Zita} and {\'A}. Kukovecz and Rita Ambrus and P. Szab{\'o}-R{\'e}v{\'e}sz",
year = "2018",
month = "3",
day = "28",
doi = "10.1088/1361-6463/aab4be",
language = "English",
volume = "51",
journal = "Journal Physics D: Applied Physics",
issn = "0022-3727",
publisher = "IOP Publishing Ltd.",
number = "16",

}

TY - JOUR

T1 - Production of meloxicam suspension using pulsed laser ablation in liquid (PLAL) technique

AU - Hopp, B.

AU - Nagy, Eszter

AU - Peták, Franciska

AU - Smausz, T.

AU - Kopniczky, Judit

AU - Tápai, Csaba

AU - Budai, Judit

AU - Papp, Ibolya Zita

AU - Kukovecz, Á.

AU - Ambrus, Rita

AU - Szabó-Révész, P.

PY - 2018/3/28

Y1 - 2018/3/28

N2 - Organic particles in the micrometer/nanometer size range can find applications in various fields. Unfortunately their production is not a straightforward task for a number of materials. In the present work the production of meloxicam particles in the micrometer range was aimed with the help of pulsed laser ablation in liquid environment (PLAL). Targets pressed from crystalline meloxicam powder were placed in distilled water and irradiated with a focused beam of a frequency doubled (532 nm) nanosecond Nd:YAG laser at 4.2-9.4 J cm-2 fluence. Morphological investigation showed that the produced suspension contained particles in the ∼100 nm to 10 μm size range (1.0-2.0 μm on average), which is about 10 times smaller than the size of the initial material. FTIR spectroscopic investigations demonstrated that the chemical composition was preserved, while x-ray diffraction and calorimetric measurements indicated partial amorphization of meloxicam during the process. The overall results suggest that the particles are mostly produced by the fragmentation of the pressed target by the recoil forces induced by the laser pulse. Long period sedimentation tests of the suspension combined with UV-vis spectroscopic analysis showed that by the method of PLAL a greater fraction of the poorly water soluble meloxicam could be dispersed and dissolved in water in a pharmaceutically preferred formation than by simple dissolution of it.

AB - Organic particles in the micrometer/nanometer size range can find applications in various fields. Unfortunately their production is not a straightforward task for a number of materials. In the present work the production of meloxicam particles in the micrometer range was aimed with the help of pulsed laser ablation in liquid environment (PLAL). Targets pressed from crystalline meloxicam powder were placed in distilled water and irradiated with a focused beam of a frequency doubled (532 nm) nanosecond Nd:YAG laser at 4.2-9.4 J cm-2 fluence. Morphological investigation showed that the produced suspension contained particles in the ∼100 nm to 10 μm size range (1.0-2.0 μm on average), which is about 10 times smaller than the size of the initial material. FTIR spectroscopic investigations demonstrated that the chemical composition was preserved, while x-ray diffraction and calorimetric measurements indicated partial amorphization of meloxicam during the process. The overall results suggest that the particles are mostly produced by the fragmentation of the pressed target by the recoil forces induced by the laser pulse. Long period sedimentation tests of the suspension combined with UV-vis spectroscopic analysis showed that by the method of PLAL a greater fraction of the poorly water soluble meloxicam could be dispersed and dissolved in water in a pharmaceutically preferred formation than by simple dissolution of it.

KW - laser ablation

KW - laser fragmentation

KW - meloxicam

KW - particle-size reduction

KW - suspension

UR - http://www.scopus.com/inward/record.url?scp=85045573356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045573356&partnerID=8YFLogxK

U2 - 10.1088/1361-6463/aab4be

DO - 10.1088/1361-6463/aab4be

M3 - Article

VL - 51

JO - Journal Physics D: Applied Physics

JF - Journal Physics D: Applied Physics

SN - 0022-3727

IS - 16

M1 - 165401

ER -