Production and in vivo imaging of 203Pb as a surrogate isotope for in vivo 212Pb internal absorbed dose studies

Domokos Máthé, Krisztián Szigeti, Nikolett Hegedus, Ildikó Horváth, Dániel S. Veres, Béla Kovács, Zoltán Szucs

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

212Pb is a clinically relevant therapeutic alpha emitter isotope. A surrogate, 203Pb, if prepared with sufficiently high specific activity could be used to estimate 212Pb in vivo absorbed doses. An improved production procedure of 203Pb with a simple, new separation method and high specific radioactivity for imaging is reported. We determined the in-vivo biodistribution of 203Pb in mice by SPECT/CT. This highlights application possibilities of 203Pb for further in vivo and clinical uses (radiolabeled 212Pb-peptide co-injection, dosimetry calculation).

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalApplied Radiation and Isotopes
Volume114
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Gamma-emitting isotope
  • NanoSPECT/CT
  • Pb
  • Pb
  • Targeted alpha therapy

ASJC Scopus subject areas

  • Radiation

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