Producing recombinant human milk proteins in the milk of livestock species.

Zsuzsanna Bösze, Mária Baranyi, C. Bruce A Whitelaw

Research output: Contribution to journalArticle

Abstract

Recombinant human proteins produced by the mammary glands of genetically modified transgenic livestock mammals represent a special aspect of milk bioactive components. For therapeutic applications, the often complex posttranslational modifications of human proteins should be recapitulated in the recombinant products. Compared to alternative production methods, mammary gland production is a viable option, underlined by a number of transgenic livestock animal models producing abundant biologically active foreign proteins in their milk. Recombinant proteins isolated from milk have reached different phases of clinical trials, with the first marketing approval for human therapeutic applications from the EMEA achieved in 2006.

Original languageEnglish
Pages (from-to)357-393
Number of pages37
JournalAdvances in Experimental Medicine and Biology
Volume606
Publication statusPublished - 2008

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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