Antidepresszánsok és aktív metabolitjaik sorsa a szervezetben

Translated title of the contribution: Prodrugs and active metabolites among antidepressive compounds

K. Tekes, Farzad Hashemi, Péter Szegi, P. Sótónyi, Rudolf Laufer, H. Kalász

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Clinical effect of drugs is influenced by the composition of the pharmaceutical preparation but substantially by the fate of the drug in the body. Metabolism of the xenobiotic drug compounds may result in pharmacologically inactive metabolites, however, metabolites with higher pharmacological activity can also be produced. These active metabolites may have different pharmacokinetic properties than the parent drug. Co-existience of the parent drug and the active metabolite in the body may significantly modify the therapeutic effect. Knowledge-based system of pharmacokinetics and metabolism of the drugs has a high impact in understanding both the pharmacokinetic and the pharmacodynamic interactions. Cytochrome P450 isoenzymes taking part in the metabolic activity of the central nervous system is a developing area in metabolic studies. In the present study CYP isoenzymes with significant activity in the brain and the clinically important pharmacokinetic and metabolic data of antidepressive compounds are summarized.

Original languageHungarian
Pages (from-to)103-110
Number of pages8
JournalNeuropsychopharmacologia Hungarica
Volume13
Issue number2
Publication statusPublished - Jun 2011

Fingerprint

Prodrugs
Pharmaceutical Preparations
Pharmacokinetics
Isoenzymes
Therapeutic Uses
Xenobiotics
Cytochrome P-450 Enzyme System
Central Nervous System
Pharmacology
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

Antidepresszánsok és aktív metabolitjaik sorsa a szervezetben. / Tekes, K.; Hashemi, Farzad; Szegi, Péter; Sótónyi, P.; Laufer, Rudolf; Kalász, H.

In: Neuropsychopharmacologia Hungarica, Vol. 13, No. 2, 06.2011, p. 103-110.

Research output: Contribution to journalArticle

Tekes, K. ; Hashemi, Farzad ; Szegi, Péter ; Sótónyi, P. ; Laufer, Rudolf ; Kalász, H. / Antidepresszánsok és aktív metabolitjaik sorsa a szervezetben. In: Neuropsychopharmacologia Hungarica. 2011 ; Vol. 13, No. 2. pp. 103-110.
@article{011bb73626b54665b7fce2846af966d7,
title = "Antidepressz{\'a}nsok {\'e}s akt{\'i}v metabolitjaik sorsa a szervezetben",
abstract = "Clinical effect of drugs is influenced by the composition of the pharmaceutical preparation but substantially by the fate of the drug in the body. Metabolism of the xenobiotic drug compounds may result in pharmacologically inactive metabolites, however, metabolites with higher pharmacological activity can also be produced. These active metabolites may have different pharmacokinetic properties than the parent drug. Co-existience of the parent drug and the active metabolite in the body may significantly modify the therapeutic effect. Knowledge-based system of pharmacokinetics and metabolism of the drugs has a high impact in understanding both the pharmacokinetic and the pharmacodynamic interactions. Cytochrome P450 isoenzymes taking part in the metabolic activity of the central nervous system is a developing area in metabolic studies. In the present study CYP isoenzymes with significant activity in the brain and the clinically important pharmacokinetic and metabolic data of antidepressive compounds are summarized.",
keywords = "Active metabolite, Antidepressant, Cyp isoenzymes in brain, Pharmacodynamic interaction, Pharmacokinetics",
author = "K. Tekes and Farzad Hashemi and P{\'e}ter Szegi and P. S{\'o}t{\'o}nyi and Rudolf Laufer and H. Kal{\'a}sz",
year = "2011",
month = "6",
language = "Hungarian",
volume = "13",
pages = "103--110",
journal = "Neuropsychopharmacologia Hungarica",
issn = "1419-8711",
publisher = "Hungarian Association of Psychopharmacology",
number = "2",

}

TY - JOUR

T1 - Antidepresszánsok és aktív metabolitjaik sorsa a szervezetben

AU - Tekes, K.

AU - Hashemi, Farzad

AU - Szegi, Péter

AU - Sótónyi, P.

AU - Laufer, Rudolf

AU - Kalász, H.

PY - 2011/6

Y1 - 2011/6

N2 - Clinical effect of drugs is influenced by the composition of the pharmaceutical preparation but substantially by the fate of the drug in the body. Metabolism of the xenobiotic drug compounds may result in pharmacologically inactive metabolites, however, metabolites with higher pharmacological activity can also be produced. These active metabolites may have different pharmacokinetic properties than the parent drug. Co-existience of the parent drug and the active metabolite in the body may significantly modify the therapeutic effect. Knowledge-based system of pharmacokinetics and metabolism of the drugs has a high impact in understanding both the pharmacokinetic and the pharmacodynamic interactions. Cytochrome P450 isoenzymes taking part in the metabolic activity of the central nervous system is a developing area in metabolic studies. In the present study CYP isoenzymes with significant activity in the brain and the clinically important pharmacokinetic and metabolic data of antidepressive compounds are summarized.

AB - Clinical effect of drugs is influenced by the composition of the pharmaceutical preparation but substantially by the fate of the drug in the body. Metabolism of the xenobiotic drug compounds may result in pharmacologically inactive metabolites, however, metabolites with higher pharmacological activity can also be produced. These active metabolites may have different pharmacokinetic properties than the parent drug. Co-existience of the parent drug and the active metabolite in the body may significantly modify the therapeutic effect. Knowledge-based system of pharmacokinetics and metabolism of the drugs has a high impact in understanding both the pharmacokinetic and the pharmacodynamic interactions. Cytochrome P450 isoenzymes taking part in the metabolic activity of the central nervous system is a developing area in metabolic studies. In the present study CYP isoenzymes with significant activity in the brain and the clinically important pharmacokinetic and metabolic data of antidepressive compounds are summarized.

KW - Active metabolite

KW - Antidepressant

KW - Cyp isoenzymes in brain

KW - Pharmacodynamic interaction

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=79959831909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959831909&partnerID=8YFLogxK

M3 - Article

C2 - 21677324

AN - SCOPUS:79959831909

VL - 13

SP - 103

EP - 110

JO - Neuropsychopharmacologia Hungarica

JF - Neuropsychopharmacologia Hungarica

SN - 1419-8711

IS - 2

ER -