Procedure for the parallel preparation of 3-imidazo[1,2-a]pyridin-3-yl- propionic acid derivatives involving meldrum's acid

János Gerencsér, Gábor Panka, Tamás Nagy, Orsolya Egyed, György Dormán, László Ürge, Ferenc Darvas

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We describe here an efficient and versatile method for the preparation of 3-imidazo[1,2-a]pyridin-3-yl-propionic acids involving, as a key step, a three-component Michael-type reaction. The extended and validated procedure allowed us to prepare various acids with three diversity points. The method was easily adaptable for parallel synthesis and an ∼2000-membered 3-imidazo[1,2-a]pyridin-3-yl-propionic acid amide library was prepared in a semiautomated manner.

Original languageEnglish
Pages (from-to)530-538
Number of pages9
JournalJournal of Combinatorial Chemistry
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 1 2005

ASJC Scopus subject areas

  • Chemistry(all)

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