A tumorprogresszió problémája: kétségek vagy remények az új évezred küszöbén?

Translated title of the contribution: Problems of tumor progression: doubts or hopes at the turn of the Millennium?

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

After major developments in the diagnosis and therapy of the primary cancer, at the turn of the century clinical oncology is still facing the major challenge: management of the disseminated disease. Cancer biology provided basic information on the genetic and biochemical background of the process, however, it turned out that the individual tumor types use a wide range of mechanisms for invasion and metastasis. Recent major discoveries concerning invasion are identification of the invasion organelle (invadopodia) and identification of certain molecular mechanisms leading to organ-selective metastatization. Prognostic pathology emerged as a new diagnostic field, specialized in predicting the metastatic behavior of the tumor based on the geno- and phenotype of the primary tumor. Ultimately, the first drugs which were designed on the principles of tumor progression entered clinical trials (angiogenesis- and MMP-inhibitors) indicating a slow but steady transfer of cancer biology knowledge to clinical oncology predicting a significant development in the management of disseminated cancer patients.

Original languageHungarian
Pages (from-to)891-899
Number of pages9
JournalOrvosi Hetilap
Volume141
Issue number17
Publication statusPublished - Apr 23 2000

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Neoplasms
Medical Oncology
Biochemical Phenomena
Angiogenesis Inhibitors
Matrix Metalloproteinase Inhibitors
Disease Management
Organelles
Genotype
Clinical Trials
Pathology
Neoplasm Metastasis
Phenotype
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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A tumorprogresszió problémája : kétségek vagy remények az új évezred küszöbén? / Tímár, J.

In: Orvosi Hetilap, Vol. 141, No. 17, 23.04.2000, p. 891-899.

Research output: Contribution to journalArticle

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