Primary pulmonary choriocarcinoma: A case report

Gyorgy L. Vegh, Ivan Szigetvári, Ibolya Soltesz, Katalin Major, Jozsef Batorfi, Janos Dancso, Laszlo Zsirai, V. Fülöp

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

BACKGROUND: Primary pulmonary choriocarcinoma (PPC) is an extremely rare clinical entity. In contrast with gestational trophoblastic tumors that show an extreme sensitivity for chemotherapy, extragonadal choriocarcinomas are mostly unresponsive to surgical and chemotherapeutic treatment and are associated with poor prognosis. The reason non-gestational choriocarcinomas behave so differently from gestational tumors is unknown. CASE: In the present case we report a 30-year-old female patient with primary choriocarcinoma of lung localization who was successfully treated with surgical resection and multiple cycles of combination chemotherapy. During her recovery she was followed up by human chorionic gonadotropin (hCG) titer measurement, and after 1 year of close surveillance of β-hCG levels her disease achieved complete remission. CONCLUSION: Because of the extreme rarity of this malignancy, there are no standardized therapeutic guidelines for treatment. The first choice in treatment of PPC is surgical resection. Postoperatively chemotherapy is indicated immediately, because definitive histologic diagnosis is not essential before chemotherapy since β-hCG is a reliable tumor marker for choriocarcinoma.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume53
Issue number5
Publication statusPublished - May 2008

Fingerprint

Choriocarcinoma
Chorionic Gonadotropin
Lung
Non-gestational Choriocarcinoma
Drug Therapy
Trophoblastic Neoplasms
Therapeutics
Tumor Biomarkers
Combination Drug Therapy
Neoplasms
Guidelines

Keywords

  • Choriocarcinoma
  • Lung cancer
  • Primary pulmonary choriocarcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Vegh, G. L., Szigetvári, I., Soltesz, I., Major, K., Batorfi, J., Dancso, J., ... Fülöp, V. (2008). Primary pulmonary choriocarcinoma: A case report. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 53(5), 369-372.

Primary pulmonary choriocarcinoma : A case report. / Vegh, Gyorgy L.; Szigetvári, Ivan; Soltesz, Ibolya; Major, Katalin; Batorfi, Jozsef; Dancso, Janos; Zsirai, Laszlo; Fülöp, V.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 53, No. 5, 05.2008, p. 369-372.

Research output: Contribution to journalArticle

Vegh, GL, Szigetvári, I, Soltesz, I, Major, K, Batorfi, J, Dancso, J, Zsirai, L & Fülöp, V 2008, 'Primary pulmonary choriocarcinoma: A case report', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 53, no. 5, pp. 369-372.
Vegh GL, Szigetvári I, Soltesz I, Major K, Batorfi J, Dancso J et al. Primary pulmonary choriocarcinoma: A case report. Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2008 May;53(5):369-372.
Vegh, Gyorgy L. ; Szigetvári, Ivan ; Soltesz, Ibolya ; Major, Katalin ; Batorfi, Jozsef ; Dancso, Janos ; Zsirai, Laszlo ; Fülöp, V. / Primary pulmonary choriocarcinoma : A case report. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2008 ; Vol. 53, No. 5. pp. 369-372.
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