Primary pulmonary choriocarcinoma: A case report

Gyorgy L. Vegh, Ivan Szigetvári, Ibolya Soltesz, Katalin Major, Jozsef Batorfi, Janos Dancso, Laszlo Zsirai, Vilmos Fulop

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12 Citations (Scopus)


BACKGROUND: Primary pulmonary choriocarcinoma (PPC) is an extremely rare clinical entity. In contrast with gestational trophoblastic tumors that show an extreme sensitivity for chemotherapy, extragonadal choriocarcinomas are mostly unresponsive to surgical and chemotherapeutic treatment and are associated with poor prognosis. The reason non-gestational choriocarcinomas behave so differently from gestational tumors is unknown. CASE: In the present case we report a 30-year-old female patient with primary choriocarcinoma of lung localization who was successfully treated with surgical resection and multiple cycles of combination chemotherapy. During her recovery she was followed up by human chorionic gonadotropin (hCG) titer measurement, and after 1 year of close surveillance of β-hCG levels her disease achieved complete remission. CONCLUSION: Because of the extreme rarity of this malignancy, there are no standardized therapeutic guidelines for treatment. The first choice in treatment of PPC is surgical resection. Postoperatively chemotherapy is indicated immediately, because definitive histologic diagnosis is not essential before chemotherapy since β-hCG is a reliable tumor marker for choriocarcinoma.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number5
Publication statusPublished - May 1 2008



  • Choriocarcinoma
  • Lung cancer
  • Primary pulmonary choriocarcinoma

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Vegh, G. L., Szigetvári, I., Soltesz, I., Major, K., Batorfi, J., Dancso, J., Zsirai, L., & Fulop, V. (2008). Primary pulmonary choriocarcinoma: A case report. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 53(5), 369-372.