Primary prevention of congenital abnormalities due to high fever related maternal diseases by antifever therapy and folic acid supplementation

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Abstract

Background: Our previous case-control studies showed an association between high fever related maternal diseases and some congenital abnormalities (CAs). The aim of this review is to summarize the result of these studies completed with available animal and clinical data from the international literature. Materials and Methods: The Hungarian studies were based on the population-based Hungarian Congenital Abnormality Registry and the Hungarian Case-Control Surveillance of Congenital Abnormalities. The latter included 22,843 cases with 25 different CA and 38,151 matched controls without CA Results: High fever related maternal diseases such as influenza, common cold with secondary complications, recurrent orofacial herpes and some other acute infectious diseases showed associations with the higher risk for isolated neural-tube defects, cleft lip ± palate, posterior cleft palate, cardiovascular CAs and multiple CAs. These findings were confirmed in the studies of etiological factors in the origin of isolated neural-tube defects, orofacial clefts and multiple CAs, in addition to congenital cataract. The most important results of animal investigations and other human studies related to the teratogenic effect of high fever are also summarized in order to achieve some general conclusions. Conclusions: Maternal high fever related diseases may associate with some CA and these CAs cover an unusual wide spectrum, which may be connected with the less specific antimitotic effect and heat stress response of hyperthermia. A higher risk for CAs can be expected due to high fever being over 38.5 °C continuing for one or more days. The timing of hyperthermia determines the risk of specific CAs. The high fever induced CAs represent a high proportion (5-7%) of CAs. The basic indication of our studies is that antifever drugs and periconceptional folic acid/multivitamin supplementation can significantly reduce the teratogenic effect of high fever related maternal diseases. Thus, CAs induced by maternal high fever related diseases are preventable.

Original languageEnglish
Pages (from-to)190-201
Number of pages12
JournalCurrent Women's Health Reviews
Volume3
Issue number3
DOIs
Publication statusPublished - Aug 2007

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Primary Prevention
Folic Acid
Fever
Mothers
Therapeutics
Multiple Abnormalities
Neural Tube Defects
Cleft Palate
Cardiovascular Abnormalities
Antimitotic Agents
Heat-Shock Response
Common Cold
Cleft Lip
Acute Disease
Cataract
Human Influenza
Communicable Diseases
Registries
Case-Control Studies

Keywords

  • Antifever drugs
  • Congenital abnormalities
  • Fever related maternal diseases
  • Folic acid and supplementation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

@article{380bf88dc97d4f238cf72e01a0e40223,
title = "Primary prevention of congenital abnormalities due to high fever related maternal diseases by antifever therapy and folic acid supplementation",
abstract = "Background: Our previous case-control studies showed an association between high fever related maternal diseases and some congenital abnormalities (CAs). The aim of this review is to summarize the result of these studies completed with available animal and clinical data from the international literature. Materials and Methods: The Hungarian studies were based on the population-based Hungarian Congenital Abnormality Registry and the Hungarian Case-Control Surveillance of Congenital Abnormalities. The latter included 22,843 cases with 25 different CA and 38,151 matched controls without CA Results: High fever related maternal diseases such as influenza, common cold with secondary complications, recurrent orofacial herpes and some other acute infectious diseases showed associations with the higher risk for isolated neural-tube defects, cleft lip ± palate, posterior cleft palate, cardiovascular CAs and multiple CAs. These findings were confirmed in the studies of etiological factors in the origin of isolated neural-tube defects, orofacial clefts and multiple CAs, in addition to congenital cataract. The most important results of animal investigations and other human studies related to the teratogenic effect of high fever are also summarized in order to achieve some general conclusions. Conclusions: Maternal high fever related diseases may associate with some CA and these CAs cover an unusual wide spectrum, which may be connected with the less specific antimitotic effect and heat stress response of hyperthermia. A higher risk for CAs can be expected due to high fever being over 38.5 °C continuing for one or more days. The timing of hyperthermia determines the risk of specific CAs. The high fever induced CAs represent a high proportion (5-7{\%}) of CAs. The basic indication of our studies is that antifever drugs and periconceptional folic acid/multivitamin supplementation can significantly reduce the teratogenic effect of high fever related maternal diseases. Thus, CAs induced by maternal high fever related diseases are preventable.",
keywords = "Antifever drugs, Congenital abnormalities, Fever related maternal diseases, Folic acid and supplementation",
author = "E. Czeizel and N. {\'A}cs and F. B{\'a}nhidy and E. Puh{\'o} and G{\'a}bor Vogt",
year = "2007",
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doi = "10.2174/157340407781387708",
language = "English",
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T1 - Primary prevention of congenital abnormalities due to high fever related maternal diseases by antifever therapy and folic acid supplementation

AU - Czeizel, E.

AU - Ács, N.

AU - Bánhidy, F.

AU - Puhó, E.

AU - Vogt, Gábor

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N2 - Background: Our previous case-control studies showed an association between high fever related maternal diseases and some congenital abnormalities (CAs). The aim of this review is to summarize the result of these studies completed with available animal and clinical data from the international literature. Materials and Methods: The Hungarian studies were based on the population-based Hungarian Congenital Abnormality Registry and the Hungarian Case-Control Surveillance of Congenital Abnormalities. The latter included 22,843 cases with 25 different CA and 38,151 matched controls without CA Results: High fever related maternal diseases such as influenza, common cold with secondary complications, recurrent orofacial herpes and some other acute infectious diseases showed associations with the higher risk for isolated neural-tube defects, cleft lip ± palate, posterior cleft palate, cardiovascular CAs and multiple CAs. These findings were confirmed in the studies of etiological factors in the origin of isolated neural-tube defects, orofacial clefts and multiple CAs, in addition to congenital cataract. The most important results of animal investigations and other human studies related to the teratogenic effect of high fever are also summarized in order to achieve some general conclusions. Conclusions: Maternal high fever related diseases may associate with some CA and these CAs cover an unusual wide spectrum, which may be connected with the less specific antimitotic effect and heat stress response of hyperthermia. A higher risk for CAs can be expected due to high fever being over 38.5 °C continuing for one or more days. The timing of hyperthermia determines the risk of specific CAs. The high fever induced CAs represent a high proportion (5-7%) of CAs. The basic indication of our studies is that antifever drugs and periconceptional folic acid/multivitamin supplementation can significantly reduce the teratogenic effect of high fever related maternal diseases. Thus, CAs induced by maternal high fever related diseases are preventable.

AB - Background: Our previous case-control studies showed an association between high fever related maternal diseases and some congenital abnormalities (CAs). The aim of this review is to summarize the result of these studies completed with available animal and clinical data from the international literature. Materials and Methods: The Hungarian studies were based on the population-based Hungarian Congenital Abnormality Registry and the Hungarian Case-Control Surveillance of Congenital Abnormalities. The latter included 22,843 cases with 25 different CA and 38,151 matched controls without CA Results: High fever related maternal diseases such as influenza, common cold with secondary complications, recurrent orofacial herpes and some other acute infectious diseases showed associations with the higher risk for isolated neural-tube defects, cleft lip ± palate, posterior cleft palate, cardiovascular CAs and multiple CAs. These findings were confirmed in the studies of etiological factors in the origin of isolated neural-tube defects, orofacial clefts and multiple CAs, in addition to congenital cataract. The most important results of animal investigations and other human studies related to the teratogenic effect of high fever are also summarized in order to achieve some general conclusions. Conclusions: Maternal high fever related diseases may associate with some CA and these CAs cover an unusual wide spectrum, which may be connected with the less specific antimitotic effect and heat stress response of hyperthermia. A higher risk for CAs can be expected due to high fever being over 38.5 °C continuing for one or more days. The timing of hyperthermia determines the risk of specific CAs. The high fever induced CAs represent a high proportion (5-7%) of CAs. The basic indication of our studies is that antifever drugs and periconceptional folic acid/multivitamin supplementation can significantly reduce the teratogenic effect of high fever related maternal diseases. Thus, CAs induced by maternal high fever related diseases are preventable.

KW - Antifever drugs

KW - Congenital abnormalities

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KW - Folic acid and supplementation

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