Primary nodal marginal zone lymphomas of splenic and MALT type

Elias Campo, Rosa Miquel, Laszlo Krenacs, Lynn Sorbara, Mark Raffeld, Elaine S. Jaffe

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110 Citations (Scopus)

Abstract

The existence of primary nodal marginal zone lymphomas (MZL) is controversial. as is their relationship to putative extranodal counterparts. Most nodal lymphomas with monocytoid B cell/marginal zone differentiation exhibit the morphologic and immunophenotypical characteristics of extranodal MALT lymphomas. Splenic marginal zone lymphoma (SMZL)is also of putative marginal zone derivation, but it differs immunophenotypically from MALT lymphoma. To clarify the relationship between nodal and extranodal MZLs and to investigate the possible existence of a nodal variant of SMZL, 36 MZL initially considered to be primary nodal neoplasms were examined. Other low- grade lymphomas with marginal zone differentiation were excluded (small lymphocytic lymphoma/chronic lymphocytic leukemia I SLL/CLL], follicular lymphoma, and mantle cell lymphoma). Six nodal MZLs showed morphologic and phenotypic characteristics similar to those of SMZL, whereas 30 tumors were more similar to MAl.T-type lymphomas. The six tumors with SMZL features showed a polymorphic infiltrate surrounding residual germinal centers with absent or very attenuated mantle cults. These lymphomas were IgD positive (6/6) but cyclin D1 (0/5), CD5 (0/6), and CD23 (0/6) negative. Five of these patients came for treatment in stage I or 11. No patient manifested splenomegaly, peripheral blood, and/or bone marrow infiltration either at diagnosis or during follow-up. Lymph nodes from 30 patients with MALT-type features showed a perisinusoidal and perivascular infiltration of monocytoid/centrocytoid cells and residual germinal centers with a relatively well-preserved mantle cuff. The neoplastic cells were negative for IgD (0/17), cyclin DI (0/8), and CD5 10/12). Seven of 16 (44%) patients with a detailed history and clinical follow-up had evidence of extranodal lymphoma. These observations suggest that most nodal B cell lymphomas with marginal zone differentiation are of the MALT type and that they are frequently associated with an extranodal component. In addition, a primary. nodal counterpart of splenic MZL also exists, and may occur in the absence of splenomegaly.

Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 1 1999

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Keywords

  • MALT lymphoma
  • Monocytoid B cell lymphoma
  • Nodal marginal zone lymphoma
  • Splenic marginal zone lymphoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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