Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments

L. Máródi, Jean Laurent Casanova

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

mAbs directed against immunologic molecules have emerged as a new class of drugs for treating patients with various immunologic conditions. However, mAb-based treatments may confer a predisposition to various infections. The authors argue that infections in individuals treated with mAbs directed against molecules of the immune system may display some similarities to those in patients with primary immunodeficiency of the corresponding mAb target. A comprehensive dissection of the tremendously diverse human primary immunodeficiencies and the careful description of their clinical features in different populations living in diverse environments thus represents an original, neglected, but promising approach to assessing the potential risk of infection associated with therapeutic mAbs, or with any therapeutic compound inhibiting a specific immunologic molecule.

Original languageEnglish
Pages (from-to)910-917
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume126
Issue number5
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Communicable Diseases
Infection
Dissection
Immune System
Therapeutics
Pharmaceutical Preparations
Population

Keywords

  • Infections
  • Monoclonal antibody therapy
  • Primary immunodeficiency diseases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments. / Máródi, L.; Casanova, Jean Laurent.

In: Journal of Allergy and Clinical Immunology, Vol. 126, No. 5, 11.2010, p. 910-917.

Research output: Contribution to journalArticle

@article{270127b6a2c84477af741ec2ea86da82,
title = "Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments",
abstract = "mAbs directed against immunologic molecules have emerged as a new class of drugs for treating patients with various immunologic conditions. However, mAb-based treatments may confer a predisposition to various infections. The authors argue that infections in individuals treated with mAbs directed against molecules of the immune system may display some similarities to those in patients with primary immunodeficiency of the corresponding mAb target. A comprehensive dissection of the tremendously diverse human primary immunodeficiencies and the careful description of their clinical features in different populations living in diverse environments thus represents an original, neglected, but promising approach to assessing the potential risk of infection associated with therapeutic mAbs, or with any therapeutic compound inhibiting a specific immunologic molecule.",
keywords = "Infections, Monoclonal antibody therapy, Primary immunodeficiency diseases",
author = "L. M{\'a}r{\'o}di and Casanova, {Jean Laurent}",
year = "2010",
month = "11",
doi = "10.1016/j.jaci.2010.08.009",
language = "English",
volume = "126",
pages = "910--917",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments

AU - Máródi, L.

AU - Casanova, Jean Laurent

PY - 2010/11

Y1 - 2010/11

N2 - mAbs directed against immunologic molecules have emerged as a new class of drugs for treating patients with various immunologic conditions. However, mAb-based treatments may confer a predisposition to various infections. The authors argue that infections in individuals treated with mAbs directed against molecules of the immune system may display some similarities to those in patients with primary immunodeficiency of the corresponding mAb target. A comprehensive dissection of the tremendously diverse human primary immunodeficiencies and the careful description of their clinical features in different populations living in diverse environments thus represents an original, neglected, but promising approach to assessing the potential risk of infection associated with therapeutic mAbs, or with any therapeutic compound inhibiting a specific immunologic molecule.

AB - mAbs directed against immunologic molecules have emerged as a new class of drugs for treating patients with various immunologic conditions. However, mAb-based treatments may confer a predisposition to various infections. The authors argue that infections in individuals treated with mAbs directed against molecules of the immune system may display some similarities to those in patients with primary immunodeficiency of the corresponding mAb target. A comprehensive dissection of the tremendously diverse human primary immunodeficiencies and the careful description of their clinical features in different populations living in diverse environments thus represents an original, neglected, but promising approach to assessing the potential risk of infection associated with therapeutic mAbs, or with any therapeutic compound inhibiting a specific immunologic molecule.

KW - Infections

KW - Monoclonal antibody therapy

KW - Primary immunodeficiency diseases

UR - http://www.scopus.com/inward/record.url?scp=78049476708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049476708&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2010.08.009

DO - 10.1016/j.jaci.2010.08.009

M3 - Article

VL - 126

SP - 910

EP - 917

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -