Primary bone marrow T-cell anaplastic large cell lymphoma with triple M gradient

Árpád Szomor, Talal Al Saati, Georges Delsol, László Kereskai, Zsuzsanna Szijártó, Hajna Losonczy

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We present a case of a 60-year-old male patient with primary bone marrow anaplastic large cell lymphoma. He was admitted to the hospital with the symptoms of anemia and fever. There was no evidence of lymphadenopathy or splenomegaly. Immunoelectrophoresis showed the presence of a triple M gradient (double IgM and an IgG), with the IgG and one of the IgM paraproteins functioning as a cryoglobulin. The patient had no hepatitis C virus infection. Bone marrow biopsy showed massive CD30-positive, ALK-negative large lymphoid cell infiltration of T-cell origin with anaplastic morphology. PCR analysis of lymphoid cells separated from the bone marrow demonstrated the presence of a B/T hybrid genotype disorder with no evidence of the t(2;5), nor t(1;2) translocations. The patient entered a period of remission following CHOP chemotherapy. The patient subsequently died of sepsis as a consequence of serious humoral immunodeficiency.

Original languageEnglish
Pages (from-to)260-262
Number of pages3
JournalPathology and Oncology Research
Issue number3
Publication statusPublished - Jan 1 2007



  • Anaplastic large cell lymphoma
  • Bone marrow
  • Immunoglobulin heavy chain gene rearrangement
  • M gradient
  • T-cell receptor gene rearrangement

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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