Arteria pulmonalis mikroembolizációt, pulmonalis hipertóniát okozó primer tüdorák

Translated title of the contribution: Primary adenocarcinoma of the lung causing pulmonary tumor thrombotic microangiopathy

András Vörös, László Kaiser, Attila Somfay, A. Pálinkás

Research output: Contribution to journalArticle

Abstract

The authors present a rare cause of pulmonary hypertension, which occurred in a 57-year-old woman. Postmortem examination discovered an adenocarcinoma with bronchioloalveolar growth pattern as a cause of severe dyspnoea, extreme pulmonary hypertension, and chronic cor pulmonale. The tumour involved all lobes of the lung. In the hilar lymph node metastasis was detectable. Histology showed tumour cell emboli in branches of the pulmonary arteries, intimal fibrosis, which was associated with fibrin precipitation and involvement of lymphatic vessels showing lymphangiosis carcinornatosa. The intrapulmonary dissemination of the adenocarcinoma could be caused by the isolated haematogenous dissemination via the thoracic duct. The authors discuss the possible pathomechanism of pulmonary hypertension and the way of tumour cell dissemination in the lung. They highlight the histological changes, which accompany the syndrome of pulmonary tumour thrombotic microangiopathy. In this case, which can be regarded rarely published in the literature, they emphasisc the differential diagnostic questions.

Original languageHungarian
Pages (from-to)1281-1285
Number of pages5
JournalOrvosi Hetilap
Volume148
Issue number27
DOIs
Publication statusPublished - Jul 8 2007

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Thrombotic Microangiopathies
Pulmonary Hypertension
Lung
Neoplasms
Adenocarcinoma
Tunica Intima
Thoracic Duct
Pulmonary Heart Disease
Lymphatic Vessels
Embolism
Fibrin
Dyspnea
Pulmonary Artery
Autopsy
Histology
Fibrosis
Lymph Nodes
Neoplasm Metastasis
Adenocarcinoma of lung
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Arteria pulmonalis mikroembolizációt, pulmonalis hipertóniát okozó primer tüdorák. / Vörös, András; Kaiser, László; Somfay, Attila; Pálinkás, A.

In: Orvosi Hetilap, Vol. 148, No. 27, 08.07.2007, p. 1281-1285.

Research output: Contribution to journalArticle

Vörös, András ; Kaiser, László ; Somfay, Attila ; Pálinkás, A. / Arteria pulmonalis mikroembolizációt, pulmonalis hipertóniát okozó primer tüdorák. In: Orvosi Hetilap. 2007 ; Vol. 148, No. 27. pp. 1281-1285.
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