Previous lung diseases and lung cancer risk

A pooled analysis from the international lung cancer consortium

Darren R. Brenner, Paolo Boffetta, Eric J. Duell, Heike Bickeböller, Albert Rosenberger, Valerie McCormack, Joshua E. Muscat, Ping Yang, H. Erich Wichmann, Irene Brueske-Hohlfeld, Ann G. Schwartz, Michele L. Cote, Anne Tjonneland, Soren Friis, Loic Le Marchand, Zuo Feng Zhang, Hal Morgenstern, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, David Zaridze & 22 others P. Rudnai, Eleonora Fabianova, Lenka Foretova, Vladimir Janout, Vladimir Bencko, Miriam Schejbalova, Paul Brennan, Ioan N. Mates, Philip Lazarus, John K. Field, Olaide Raji, John R. McLaughlin, Geoffrey Liu, John Wiencke, Monica Neri, Donatella Ugolini, Angeline S. Andrew, Qing Lan, Wei Hu, Irene Orlow, Bernard J. Park, Rayjean J. Hung

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (19842011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95 confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95 CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk 1.48, 95 CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk 1.57, 95 CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.

Original languageEnglish
Pages (from-to)573-585
Number of pages13
JournalAmerican Journal of Epidemiology
Volume176
Issue number7
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Lung Diseases
Lung Neoplasms
Emphysema
Confidence Intervals
Pneumonia
Tuberculosis
Chronic Bronchitis
Logistic Models
Smoking
Tobacco Use
North America
Proportional Hazards Models
Histology

Keywords

  • bronchitis
  • chronic
  • chronic obstructive
  • emphysema
  • lung diseases
  • lung neoplasms
  • meta-analysis
  • pneumonia
  • pulmonary disease
  • tuberculosis

ASJC Scopus subject areas

  • Epidemiology

Cite this

Brenner, D. R., Boffetta, P., Duell, E. J., Bickeböller, H., Rosenberger, A., McCormack, V., ... Hung, R. J. (2012). Previous lung diseases and lung cancer risk: A pooled analysis from the international lung cancer consortium. American Journal of Epidemiology, 176(7), 573-585. https://doi.org/10.1093/aje/kws151

Previous lung diseases and lung cancer risk : A pooled analysis from the international lung cancer consortium. / Brenner, Darren R.; Boffetta, Paolo; Duell, Eric J.; Bickeböller, Heike; Rosenberger, Albert; McCormack, Valerie; Muscat, Joshua E.; Yang, Ping; Wichmann, H. Erich; Brueske-Hohlfeld, Irene; Schwartz, Ann G.; Cote, Michele L.; Tjonneland, Anne; Friis, Soren; Le Marchand, Loic; Zhang, Zuo Feng; Morgenstern, Hal; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Zaridze, David; Rudnai, P.; Fabianova, Eleonora; Foretova, Lenka; Janout, Vladimir; Bencko, Vladimir; Schejbalova, Miriam; Brennan, Paul; Mates, Ioan N.; Lazarus, Philip; Field, John K.; Raji, Olaide; McLaughlin, John R.; Liu, Geoffrey; Wiencke, John; Neri, Monica; Ugolini, Donatella; Andrew, Angeline S.; Lan, Qing; Hu, Wei; Orlow, Irene; Park, Bernard J.; Hung, Rayjean J.

In: American Journal of Epidemiology, Vol. 176, No. 7, 10.2012, p. 573-585.

Research output: Contribution to journalArticle

Brenner, DR, Boffetta, P, Duell, EJ, Bickeböller, H, Rosenberger, A, McCormack, V, Muscat, JE, Yang, P, Wichmann, HE, Brueske-Hohlfeld, I, Schwartz, AG, Cote, ML, Tjonneland, A, Friis, S, Le Marchand, L, Zhang, ZF, Morgenstern, H, Szeszenia-Dabrowska, N, Lissowska, J, Zaridze, D, Rudnai, P, Fabianova, E, Foretova, L, Janout, V, Bencko, V, Schejbalova, M, Brennan, P, Mates, IN, Lazarus, P, Field, JK, Raji, O, McLaughlin, JR, Liu, G, Wiencke, J, Neri, M, Ugolini, D, Andrew, AS, Lan, Q, Hu, W, Orlow, I, Park, BJ & Hung, RJ 2012, 'Previous lung diseases and lung cancer risk: A pooled analysis from the international lung cancer consortium', American Journal of Epidemiology, vol. 176, no. 7, pp. 573-585. https://doi.org/10.1093/aje/kws151
Brenner, Darren R. ; Boffetta, Paolo ; Duell, Eric J. ; Bickeböller, Heike ; Rosenberger, Albert ; McCormack, Valerie ; Muscat, Joshua E. ; Yang, Ping ; Wichmann, H. Erich ; Brueske-Hohlfeld, Irene ; Schwartz, Ann G. ; Cote, Michele L. ; Tjonneland, Anne ; Friis, Soren ; Le Marchand, Loic ; Zhang, Zuo Feng ; Morgenstern, Hal ; Szeszenia-Dabrowska, Neonila ; Lissowska, Jolanta ; Zaridze, David ; Rudnai, P. ; Fabianova, Eleonora ; Foretova, Lenka ; Janout, Vladimir ; Bencko, Vladimir ; Schejbalova, Miriam ; Brennan, Paul ; Mates, Ioan N. ; Lazarus, Philip ; Field, John K. ; Raji, Olaide ; McLaughlin, John R. ; Liu, Geoffrey ; Wiencke, John ; Neri, Monica ; Ugolini, Donatella ; Andrew, Angeline S. ; Lan, Qing ; Hu, Wei ; Orlow, Irene ; Park, Bernard J. ; Hung, Rayjean J. / Previous lung diseases and lung cancer risk : A pooled analysis from the international lung cancer consortium. In: American Journal of Epidemiology. 2012 ; Vol. 176, No. 7. pp. 573-585.
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abstract = "To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (19842011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95 confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95 CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk 1.48, 95 CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk 1.57, 95 CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.",
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