A humán papillomavírus (HPV) okozta rosszindulatú daganatok megelozése védooltással és a klasszikus nogyógyászati diagnosztika módszereivel

Translated title of the contribution: Prevention of malignant tumours caused by human papilloma virus (HPV) by vaccination and techniques of classical gynecological diagnostics

G. Berencsi, I. Sziller, Márta Melles

Research output: Contribution to journalArticle

Abstract

The "gold standard" of the gynecological examinations is even today the classical clinical examination completed with the digital colposcopy, the Pap smears prepared from transport media and histological examination of biopsy material. Without these classical examinations one cannot evaluate the results of the molecular tests detecting papillomaviruses. The majority (70 to 90%) of the primary clinical symptoms caused by papillomaviruses recovers spontaneously. The recovery can be supported by "imiquimod" (Aldara) which is an immunostimulant - inducing interferon gamma and the production of interleukins, since papillomavirus infection is able to prevent the production of these mediators through its blocking effect to the innate immunity. Prevention is the main aim of the contemporary public health facilitated by the modern gene technology. The tetravalent vaccine (types 6, 11, 16 and 18) is harmless, since no tumour inducing genes are included. The empty capsids are manufactured in yeast cells and purified to a high degree similar to that of hepatitis B vaccine. The tetravalent vaccine is a preventive vaccine. It will be useful for the teenagers, who have not acquired yet the most common papillomavirus types. There is intensive research going on in order to create therapeutical vaccines, which might be effective also in people of higher age who had acquired certain virus types before vaccination, and may possess clinical symptoms, too. Men are the source of papillomavirus infection of the ladies. Therefore vaccination of both genders will be indicated. The importance of the classical diagnostic procedures will not be diminished even under the umbrella of vaccination, since the preventive efforts were shown to be fully effective, if the clinical examinations, colposcopy and pap smears, biopsies are regularly performed in the patients with clinical symptoms increasing the rate of recovery above 90%. About 13 to 15 subtypes of human papillomaviruses may induce malignant processes. These are also present and most frequent in Hungary both in sexually transmitted infections and in the cancers of head and neck.

Original languageHungarian
Pages (from-to)1449-1453
Number of pages5
JournalOrvosi Hetilap
Volume147
Issue number31
Publication statusPublished - Aug 6 2006

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Papillomaviridae
imiquimod
Vaccination
Vaccines
Papanicolaou Test
Colposcopy
Papillomavirus Infections
Neoplasms
Biopsy
Immunologic Adjuvants
Hepatitis B Vaccines
Gynecological Examination
Hungary
Capsid
Interleukins
Head and Neck Neoplasms
Sexually Transmitted Diseases
Innate Immunity
Genes
Interferon-gamma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "A hum{\'a}n papillomav{\'i}rus (HPV) okozta rosszindulat{\'u} daganatok megeloz{\'e}se v{\'e}doolt{\'a}ssal {\'e}s a klasszikus nogy{\'o}gy{\'a}szati diagnosztika m{\'o}dszereivel",
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AB - The "gold standard" of the gynecological examinations is even today the classical clinical examination completed with the digital colposcopy, the Pap smears prepared from transport media and histological examination of biopsy material. Without these classical examinations one cannot evaluate the results of the molecular tests detecting papillomaviruses. The majority (70 to 90%) of the primary clinical symptoms caused by papillomaviruses recovers spontaneously. The recovery can be supported by "imiquimod" (Aldara) which is an immunostimulant - inducing interferon gamma and the production of interleukins, since papillomavirus infection is able to prevent the production of these mediators through its blocking effect to the innate immunity. Prevention is the main aim of the contemporary public health facilitated by the modern gene technology. The tetravalent vaccine (types 6, 11, 16 and 18) is harmless, since no tumour inducing genes are included. The empty capsids are manufactured in yeast cells and purified to a high degree similar to that of hepatitis B vaccine. The tetravalent vaccine is a preventive vaccine. It will be useful for the teenagers, who have not acquired yet the most common papillomavirus types. There is intensive research going on in order to create therapeutical vaccines, which might be effective also in people of higher age who had acquired certain virus types before vaccination, and may possess clinical symptoms, too. Men are the source of papillomavirus infection of the ladies. Therefore vaccination of both genders will be indicated. The importance of the classical diagnostic procedures will not be diminished even under the umbrella of vaccination, since the preventive efforts were shown to be fully effective, if the clinical examinations, colposcopy and pap smears, biopsies are regularly performed in the patients with clinical symptoms increasing the rate of recovery above 90%. About 13 to 15 subtypes of human papillomaviruses may induce malignant processes. These are also present and most frequent in Hungary both in sexually transmitted infections and in the cancers of head and neck.

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