Prevention of indomethacin-induced acute gastric mucosal injury by spermine in the rat

Gy Buzás, Zs Demel, J. Józan, J. Hamar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of spermine tetrahydrochloride was investigated on the indomethacin-induced acute mucosal injury and mucosal lipid peroxidation in rats. Spermine was given orally at doses of 25, 75 and 150 mg/kg and, intraperitoneally at 10, 25 and 50 mg/kg 1 hour before 25 mg/kg indomethacin administration. Macroscopic injury was measured by the use of a stereomicroscope. Mucosal malondialdehyde (MDA) levels were determined by an HPLC method. Oral spermine reduced dose-dependently the extent of macroscopic injury from 22.87±2.88 mm to 11.8±2.48 mm (p

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalActa Physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - 1996

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Spermine
Indomethacin
Stomach
Wounds and Injuries
Malondialdehyde
Lipid Peroxidation
High Pressure Liquid Chromatography

Keywords

  • Acute gastric mucosal injury
  • Free radicals
  • Indomethacin
  • Malondialdehyde
  • Polyamine
  • Spermine

ASJC Scopus subject areas

  • Physiology

Cite this

Prevention of indomethacin-induced acute gastric mucosal injury by spermine in the rat. / Buzás, Gy; Demel, Zs; Józan, J.; Hamar, J.

In: Acta Physiologica Hungarica, Vol. 84, No. 3, 1996, p. 251-258.

Research output: Contribution to journalArticle

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