A korai kezdetu szivinfarktus megelozese a familiaris hypercholesterinaemia felismerese es kezelese reven - A MED-PED FH program

Translated title of the contribution: Prevention of early onset coronary artery disease due to the early diagnoses and treatment of familiar hypercholesterolemia - The MED-PED FH Project

Research output: Contribution to journalArticle

Abstract

Coronary artery disease is the leading cause of death in Hungary. Recent progress in human genetics provides new possibilities for the prevention of common disorders e.g. early onset coronary artery disease including familial hypercholesterolemia (FH). FH is an inherited (autosomal dominant) disorder that results in twice the normal blood levels of cholesterol. Each child of an affected parent has a 50% chance of also having FH. It is estimated that 10 million people worldwide are afflicted with this disorder and one in 500 persons is affected. Without treatment, they will die a early from a heart attack - men almost always between the ages of 35 and 55 and women between 55 and 75. The 'Make Early Diagnosis and Prevent Early Death' (MED-PED) FH Project is an international effort aimed at identifying and appropriately treating persons who have FH and consequently are at high risk of premature death from a heart attack. The diagnosis is based on positive family history (early onset coronary artery disease), high blood cholesterol and LDL, normal triglyceride. The treatment itself is simple: a diet low in fat and cholesterol, medication (statins) and modification of other risk factors, such as smoking cessation. A network of lipid clinics has been established within MED-PED FH Project in Hungary. In addition, feasibility study was launched in the periconceptional care to incorporate potential parents to the MED-PED FH Project. The preliminary results of this model are presented. The purpose of this review is to stimulate Hungarian pharmacists for an active participation in the MED-PED FH Project.

Original languageHungarian
Pages (from-to)464-478
Number of pages15
JournalGyogyszereszet
Volume41
Issue number8
Publication statusPublished - 1997

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Hyperlipoproteinemia Type II
Hypercholesterolemia
Coronary Artery Disease
Early Diagnosis
Hungary
Cholesterol
Therapeutics
Myocardial Infarction
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Fat-Restricted Diet
Premature Mortality
Medical Genetics
Feasibility Studies
Smoking Cessation
Pharmacists
Cause of Death
Parents
Lipids

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "A korai kezdetu szivinfarktus megelozese a familiaris hypercholesterinaemia felismerese es kezelese reven - A MED-PED FH program",
abstract = "Coronary artery disease is the leading cause of death in Hungary. Recent progress in human genetics provides new possibilities for the prevention of common disorders e.g. early onset coronary artery disease including familial hypercholesterolemia (FH). FH is an inherited (autosomal dominant) disorder that results in twice the normal blood levels of cholesterol. Each child of an affected parent has a 50{\%} chance of also having FH. It is estimated that 10 million people worldwide are afflicted with this disorder and one in 500 persons is affected. Without treatment, they will die a early from a heart attack - men almost always between the ages of 35 and 55 and women between 55 and 75. The 'Make Early Diagnosis and Prevent Early Death' (MED-PED) FH Project is an international effort aimed at identifying and appropriately treating persons who have FH and consequently are at high risk of premature death from a heart attack. The diagnosis is based on positive family history (early onset coronary artery disease), high blood cholesterol and LDL, normal triglyceride. The treatment itself is simple: a diet low in fat and cholesterol, medication (statins) and modification of other risk factors, such as smoking cessation. A network of lipid clinics has been established within MED-PED FH Project in Hungary. In addition, feasibility study was launched in the periconceptional care to incorporate potential parents to the MED-PED FH Project. The preliminary results of this model are presented. The purpose of this review is to stimulate Hungarian pharmacists for an active participation in the MED-PED FH Project.",
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