Prevention of congenital abnormalities by vitamin A

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The objective of the study was to determine the human teratogenic risk of vitamin A supplementation during pregnancy. Paired analysis of cases with congenital abnormalities and matched healthy controls was performed in the large population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. Of 35 727 pregnant women who had control infants without defects, 3399 (9.5 %) were treated with vitamin A. Of 20 830 pregnant women who had case offspring with congenital abnormalities, 1642 (7.9%) were treated with vitamin A, a rate that is significantly lower than that of the control group (p <0.001). The case-control pair analysis also showed a lower rate of vitamin A treatment during pregnancy and in the first trimester of gestation in most congenital abnormality groups. Thus, use of low or moderate doses of vitamin A (<10,000 IU) during the first trimester of pregnancy (i.e., organogenesis) is not teratogenic but presents some protective effect to the fetus.

Original languageEnglish
Pages (from-to)219-231
Number of pages13
JournalInternational Journal for Vitamin and Nutrition Research
Volume68
Issue number4
Publication statusPublished - 1998

Fingerprint

congenital abnormalities
Vitamin A
vitamin A
pregnancy
pregnant women
First Pregnancy Trimester
Pregnant Women
Pregnancy
Organogenesis
organogenesis
protective effect
fetus
Fetus
Control Groups
monitoring
dosage
Population

Keywords

  • Antiteratogenic effect
  • Case-Control study
  • Congenital abnormalities
  • Teratogenic effect
  • Vitamin A

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Prevention of congenital abnormalities by vitamin A. / Czeizel, E.; Rockenbauer, M.

In: International Journal for Vitamin and Nutrition Research, Vol. 68, No. 4, 1998, p. 219-231.

Research output: Contribution to journalArticle

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