Prevention of apoptosis reperfusion renal injury by calcium channel blockers

Éva Toronyi, J. Hamar, Ferenc Ferner, B. Szende

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Apoptosis has been shown in the literature to be the form of cell death occurring in renal tubular epithelial cells during the reperfusion phase after brief periods of renal ischemia. In the present study apoptosis was examined in the rat kidney in the first 24 hours after 30 min ischemia and apoptosis was influenced by administration of the Ca channel blockers Verapamil, Bepridil, Nifedipin and Sensit. Apoptosis was observed in the renal tubular cells two hours after the start of reperfusion and reached in maximum at hour 6. All above mentioned Ca channel blockers decreased the occurrence and degree of apoptosis.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalExperimental and Toxicologic Pathology
Volume51
Issue number3
Publication statusPublished - 1999

Fingerprint

Calcium Channel Blockers
Reperfusion Injury
Apoptosis
Kidney
Reperfusion
Fendiline
Ischemia
Bepridil
Cell death
Verapamil
Rats
Cell Death
Epithelial Cells

Keywords

  • Apoptosis
  • Calcium channel blockers
  • Kidney, ischemia
  • Renal injury
  • Reperfusion, kidney

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Prevention of apoptosis reperfusion renal injury by calcium channel blockers. / Toronyi, Éva; Hamar, J.; Ferner, Ferenc; Szende, B.

In: Experimental and Toxicologic Pathology, Vol. 51, No. 3, 1999, p. 209-212.

Research output: Contribution to journalArticle

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