Prevention of Alcohol-Induced Inflammation of Murine Small Intestine by MicroRNA-155 Deficiency

Dora Lippai, G. Szabó

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chronic alcohol consumption impairs gut barrier function and causes inflammatory changes. While contribution of alcohol to inflammation and loss of barrier function is established, mechanisms by which alcohol triggers inflammation in small intestine are partially understood. The miRNAs are fine tuners of gene expression in inflammation. This chapter focuses on short- and long-term alcohol-induced inflammatory changes in small intestine and contribution of miRNA-155 to inflammation in small intestine and cerebellum. Acute and chronic alcohol administration increases serum endotoxin levels, intestinal NF-κB activation, and TNF-α mRNA levels. Endotoxin-based toll-like receptor stimulation results in upregulation of miRNA-155 and TNF-α. Both miRNA-155 and TNF-α increase after chronic alcohol feeding in murine small intestine. miRNA-155 deficiency protects from chronic alcohol-induced intestinal and cerebellar inflammation in mice. miRNA-155 might be a potential modulatory therapeutic target for future studies.

Original languageEnglish
Title of host publicationInsights to Neuroimmune Biology: Second Edition
PublisherElsevier Inc.
Pages243-256
Number of pages14
ISBN (Print)9780128017708
DOIs
Publication statusPublished - Jan 26 2016

Fingerprint

MicroRNAs
Small Intestine
Alcohols
Inflammation
Endotoxins
Toll-Like Receptors
Alcohol Drinking
Cerebellum
Up-Regulation
Gene Expression
Messenger RNA
Serum

Keywords

  • Alcohol
  • Binge
  • Cerebellum
  • Gut barrier
  • Inflammation
  • MiRNA
  • MiRNA-155
  • Proximal intestine
  • TNF-α

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Prevention of Alcohol-Induced Inflammation of Murine Small Intestine by MicroRNA-155 Deficiency. / Lippai, Dora; Szabó, G.

Insights to Neuroimmune Biology: Second Edition. Elsevier Inc., 2016. p. 243-256.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lippai, Dora ; Szabó, G. / Prevention of Alcohol-Induced Inflammation of Murine Small Intestine by MicroRNA-155 Deficiency. Insights to Neuroimmune Biology: Second Edition. Elsevier Inc., 2016. pp. 243-256
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