Prevention by macrocortin of global cerebral ischemia in sprague-dawley rats

Mátyás Koltai, Árpád Tósaki, Géza Ádám, Ferenc Joó, György Nemecz, László Szekeres

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have previously shown that dexamethasone protectas female Sprague-Dawley CFY rats against global cerebral ischemia induced by bilateral carotid artery ligation. In the present study, macrocortin derived from rat peritoneal cells exposed to dexamethasone was found to exhibit antiphospholipase A2 activity and to provide significant protection against the fatal consequences of carotid artery ligation. These results suggest that the cerebroprotective effect of glucocorticoids may be related to macrocortin production.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalEuropean Journal of Pharmacology
Volume105
Issue number3-4
DOIs
Publication statusPublished - Oct 15 1984

Keywords

  • Carotid artery ligation
  • Dexamethasone
  • Female Sprague-Dawley rats
  • Global cerebral ischemia
  • Intracisternal administration
  • Macrocortin

ASJC Scopus subject areas

  • Pharmacology

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