Prevention by dexamethasone of the marked antiarrhythmic effects of preconditioning induced 20 h after rapid cardiac pacing

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Abstract

Dogs were paced, via a pacing electrode in the right ventricle, for four 5 min periods at a rate of 220 beats min−1. On the following day they were reanaesthetized, thoracotomized and the left anterior descending coronary artery occluded for 25 min. Pacing markedly reduced the severity of ischaemia‐induced arrhythmias (e.g. reduction in VF from 45% in unpaced dogs to 10% in paced dogs; P < 0.05), an effect reversed by dexamethasone (4 mg kg−1 i.v., 45 min prior to pacing). This protection may be due to the induction of nitric oxide synthase or cyclo‐oxygenase. 1994 British Pharmacological Society

Original languageEnglish
Pages (from-to)1081-1082
Number of pages2
JournalBritish journal of pharmacology
Volume113
Issue number4
DOIs
Publication statusPublished - Dec 1994

Keywords

  • Ischaemic preconditioning
  • antiarrhythmic effect of cardiac pacing
  • dexamethasone
  • nitric oxide
  • rapid cardiac pacing
  • second window of protection
  • ventricular arrhythmias

ASJC Scopus subject areas

  • Pharmacology

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