Prevalence of the carbapenemase gene (cfiA) among clinical and normal flora isolates of Bacteroides species in Hungary

J. Sóki, E. Urbán, I. Szöke, E. Fodor, E. Nagy

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The carbapenemase gene (cfiA) was detected in 4 (5.7%) of 70 clinical isolates of Bacteroides fragilis from different parts of Hungary. Among 24 other Bacteroides species isolated from infectious processes or from normal faecal flora, none was cfiA-positive. The MIC of imipenem and meropenem for all cfiA-positive B. fragilis isolates was ≤0.25 mg/L, but 17% of the B. fragilis and 46% of the non-fragilis Bacteroides isolates exhibited reduced susceptibility to imipenem (MICs 0.5-2 mg/L). Only one of these isolates produced increased levels of β-lactamase. No difference was observed in the outer-membrane proteins of B. fragilis isolates that harboured the cfiA gene and those with reduced susceptibility to imipenem.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalJournal of Medical Microbiology
Volume49
Issue number5
Publication statusPublished - 2000

Fingerprint

Bacteroides fragilis
Bacteroides
Hungary
Imipenem
meropenem
Genes
Membrane Proteins
carbapenemase

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

@article{3eb3ef0561ee42a1b688bedf37536772,
title = "Prevalence of the carbapenemase gene (cfiA) among clinical and normal flora isolates of Bacteroides species in Hungary",
abstract = "The carbapenemase gene (cfiA) was detected in 4 (5.7{\%}) of 70 clinical isolates of Bacteroides fragilis from different parts of Hungary. Among 24 other Bacteroides species isolated from infectious processes or from normal faecal flora, none was cfiA-positive. The MIC of imipenem and meropenem for all cfiA-positive B. fragilis isolates was ≤0.25 mg/L, but 17{\%} of the B. fragilis and 46{\%} of the non-fragilis Bacteroides isolates exhibited reduced susceptibility to imipenem (MICs 0.5-2 mg/L). Only one of these isolates produced increased levels of β-lactamase. No difference was observed in the outer-membrane proteins of B. fragilis isolates that harboured the cfiA gene and those with reduced susceptibility to imipenem.",
author = "J. S{\'o}ki and E. Urb{\'a}n and I. Sz{\"o}ke and E. Fodor and E. Nagy",
year = "2000",
language = "English",
volume = "49",
pages = "427--430",
journal = "Journal of Medical Microbiology",
issn = "0022-2615",
publisher = "Society for General Microbiology",
number = "5",

}

TY - JOUR

T1 - Prevalence of the carbapenemase gene (cfiA) among clinical and normal flora isolates of Bacteroides species in Hungary

AU - Sóki, J.

AU - Urbán, E.

AU - Szöke, I.

AU - Fodor, E.

AU - Nagy, E.

PY - 2000

Y1 - 2000

N2 - The carbapenemase gene (cfiA) was detected in 4 (5.7%) of 70 clinical isolates of Bacteroides fragilis from different parts of Hungary. Among 24 other Bacteroides species isolated from infectious processes or from normal faecal flora, none was cfiA-positive. The MIC of imipenem and meropenem for all cfiA-positive B. fragilis isolates was ≤0.25 mg/L, but 17% of the B. fragilis and 46% of the non-fragilis Bacteroides isolates exhibited reduced susceptibility to imipenem (MICs 0.5-2 mg/L). Only one of these isolates produced increased levels of β-lactamase. No difference was observed in the outer-membrane proteins of B. fragilis isolates that harboured the cfiA gene and those with reduced susceptibility to imipenem.

AB - The carbapenemase gene (cfiA) was detected in 4 (5.7%) of 70 clinical isolates of Bacteroides fragilis from different parts of Hungary. Among 24 other Bacteroides species isolated from infectious processes or from normal faecal flora, none was cfiA-positive. The MIC of imipenem and meropenem for all cfiA-positive B. fragilis isolates was ≤0.25 mg/L, but 17% of the B. fragilis and 46% of the non-fragilis Bacteroides isolates exhibited reduced susceptibility to imipenem (MICs 0.5-2 mg/L). Only one of these isolates produced increased levels of β-lactamase. No difference was observed in the outer-membrane proteins of B. fragilis isolates that harboured the cfiA gene and those with reduced susceptibility to imipenem.

UR - http://www.scopus.com/inward/record.url?scp=0034020055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034020055&partnerID=8YFLogxK

M3 - Article

C2 - 10798555

AN - SCOPUS:0034020055

VL - 49

SP - 427

EP - 430

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

SN - 0022-2615

IS - 5

ER -