A metiléntetrahidrofolát-reduktáz (MTHFR) gén polimorfizmusának (C677T) magyarországi gyakorisága.

Translated title of the contribution: Prevalence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) in the Hungarian population

E. Czeizel, L. Tímár, L. Botto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

MTHFR encodes a critical enzyme in folate and homocysteine metabolism and the C677T allele of the MTHFR gene has some association with an increased risk for neural-tube defects and for adult cardiovascular diseases. As part of an international collaborative study the prevalence of C677T homozygous genotype was 11.1% while the frequency of C677T heterozygous condition was 45.2% in the Hungarian neonate sample. These findings underscore the clinical importance of the C677T variant in the Hungarian population and urge population-based prevention of conditions related to such gene.

Original languageHungarian
Pages (from-to)1227-1229
Number of pages3
JournalOrvosi hetilap
Volume142
Issue number23
Publication statusPublished - Jun 10 2001

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ASJC Scopus subject areas

  • Medicine(all)

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