A Leiden-mutáció prevalenciája a különbözó gastrointestinalis kórképekben.

Translated title of the contribution: Prevalence of Leiden mutation in various gastrointestinal disorders

Gyula Mózsik, Mária Figler, Beáta Gasztonyi, Oszkár Karádi, Hajna Losonzy, Agnes Nagy, Zsuzsanna Nagy, Alajos Pár, György Rumi, Gábor Sütó, Aron Vincze

Research output: Contribution to journalReview article

4 Citations (Scopus)


Molecular biological examinations have been carried out by the authors from 1995 in patients with different haemostasis, very recently these types of the studies were done in patients with different gastrointestinal (Helicobacter pylori-induced gastritis, hepatitis C infection, ileitis terminalis, ulcerative colitis, colon polyposis and adenocarcinoma in polyps) disorders. AIM, PATIENTS, METHOD: The Leiden mutation was detected by polymerase chain reaction (PCR) in 1354 healthy persons and patients with different GI disorders. RESULTS: The results of Leiden prevalence in patients with different gastrointestinal disorders were compared to those obtained in patients with venous thrombosis and familiar thrombophilia. The authors indicated that the prevalence of heterozygous Leiden positive persons was 5.9% in healthy (n = 87) and blood donors (n = 600). The prevalence of heterozygous Leiden mutation was 27% in patents who under went venous thrombosis (n = 300; P < 0.001), 38% in patients with familial thrombophilia (n = 116; P < 0.001). The prevalence of Leiden mutation was 0 in patients with Helicobacter pylori-induced gastritis (n = 24), 8% in hepatitis C infections (n = 75), 14.28% in Crohn's disease, (n = 49; P < 0.01), 27.5% in ulcerative colitis (n = 35; P < 0.001), 44% in colon polyposis (n = 59; P < 0.001) and 55% in situ adenocarcinomas (in polyposis) (n = 9; P < 0.001). CONCLUSION: The presented results suggest that the Leiden mutation is involved in patients with different inflammatory bowel disease, colon polyposis, as one of the suggested genetic factors.

Translated title of the contributionPrevalence of Leiden mutation in various gastrointestinal disorders
Original languageHungarian
Pages (from-to)447-450
Number of pages4
JournalOrvosi hetilap
Issue number9
Publication statusPublished - Mar 3 2002

ASJC Scopus subject areas

  • Medicine(all)

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