Prevalence of human herpesvirus-8 infection in HIV-positive patients with and without Kaposi's sarcoma in Hungary

Erika Szalai, Zsuzsanna Gerlei, János Szlávik, Györgyi Szládek, Ravi Patel, János Hunyadi, Lajos Gergely, Attila Juhász

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Human herpesvirus-8 (HHV-8) infection of 130 Hungarian HIV-positive individuals with or without Kaposi's sarcoma was investigated from 158 serum and 122 peripheral blood samples using anti-latency-associated nuclear antigen (LANA) indirect immunofluorescence assay (IFA), recombinant orf65 and orfK8.1 antigen enzyme-linked immunosorbent assays (ELISAs), Western blot assays and orf26 specific nested polymerase chain reaction (PCR). The overall prevalence of HHV-8 infection was found to be 31.5% (41/130) among the Hungarian HIV-positive patients. This seroprevalence rate is 7-11-fold higher than that of healthy HIV-negative blood donors in Hungary. The highest prevalence of HHV-8 infection (36.1%, 35/97) was observed in homo- or bisexual patients. Similar to the serologic results, HHV-8 DNA was not always detectable in all serial samples previously shown to be positive for HHV-8 DNA.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalFEMS Immunology and Medical Microbiology
Volume43
Issue number2
DOIs
Publication statusPublished - Feb 1 2005

    Fingerprint

Keywords

  • Epidemiology
  • Human herpesvirus-8
  • Serology
  • orf65
  • orf73
  • orfK8.1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this