Prevalence of HBV genotypes in Central and Eastern Europe

Katja Deterding, Ileana Constantinescu, Filofteia Daniela Nedelcu, Judit Gervain, Vratislav Némeček, Otakar Srtunecky, Adriana Vince, Ivica Grgurevic, Krzysztof P. Bielawski, Małgorzata Zalewska, Thomas Bock, Arvydas Ambrozaitis, Janusz Stanczak, Mária Takács, Vladimir Chulanov, Janusz Ślusarczyk, Marcela Dražd'áková, Johannes Wiegand, Markus Cornberg, Michael P. MannsHeiner Wedemeyer

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The importance of hepatitis B virus (HBV) genotypes for disease progression and response to interferon-alpha-based treatment is well established. While almost all patients in the Mediterranean area are infected with HBV genotype D, HBV genotype A is dominant in Northern Europe. However, the distribution of HBV genotypes is unknown for several Central and Eastern European countries. Data are described of 1313 HBsAg-positive patients recruited at 14 referral centers in eight countries. There were only very few cases of HBV genotype B, C, E, F, and H infection while HBV genotypes A and D were found in 42% and 48% of patients, respectively. Eight percent of patients had positive bands for more than one genotype using the hybridization assay. The frequency of genotype A was higher in Poland (77%) and the Czech Republic (67%) as compared to Hungary (47%), Lithuania (41%), Croatia (8%), and Germany (32%). In contrast, HBV genotype D was most frequent in Croatian, Romanian, and Russian patients with 80%, 67%, and 93% of cases, respectively. In conclusion, HBV genotype A versus D showed significantly different distribution patterns in Central and Eastern Europe which deserves consideration for national guidelines and treatment decisions.

Original languageEnglish
Pages (from-to)1707-1711
Number of pages5
JournalJournal of Medical Virology
Issue number10
Publication statusPublished - Oct 2008



  • HBV genotype
  • Hepatitis B

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Deterding, K., Constantinescu, I., Nedelcu, F. D., Gervain, J., Némeček, V., Srtunecky, O., Vince, A., Grgurevic, I., Bielawski, K. P., Zalewska, M., Bock, T., Ambrozaitis, A., Stanczak, J., Takács, M., Chulanov, V., Ślusarczyk, J., Dražd'áková, M., Wiegand, J., Cornberg, M., ... Wedemeyer, H. (2008). Prevalence of HBV genotypes in Central and Eastern Europe. Journal of Medical Virology, 80(10), 1707-1711.